ArticleeLife2023
Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- Conserved signaling pathways and transcriptional regulators drive ovarian aging across species.Poultry science · 2026Article
- The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility.Current issues in molecular biology · 2026Review
- Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling.bioRxiv : the preprint server for biology · 2026Article
- CACNA2D1 promotes ovulation by regulating ovarian immune cell infiltration.BMC veterinary research · 2026Article
- Aging disrupts spatiotemporal coordination in the cycling murine ovary.Nature aging · 2026Article
- Article
- Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary.bioRxiv : the preprint server for biology · 2026Article
- Multicellular origins of murine ovarian inflammaging.Communications biology · 2026Article
- Single-cell dissection of regulated cell death dynamics in ovarian aging.Journal of ovarian research · 2026Article
- Whole-grain black rice diet rewires the single-cell transcriptomic landscape of age-related ovarian decline in mice.Science China. Life sciences · 2026Article
- Single-Cell Transcriptomic Atlas of Chicken Ovarian Aging and Cancer Drives Prognostic Model Development.Cancers · 2026Article
- Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging.Aging cell · 2026Article
- The role of IL-33/ST2 signaling in female reproductive diseases.Frontiers in cell and developmental biology · 2026Review
- From gut to gamete: how the microbiome influences fertility and preconception health.Microbiome · 2025Review
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics†.Biology of reproduction · 2025Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovary.Journal of ovarian research · 2025Article
- Systematic characterization of the ovarian landscape across mouse menopause models.bioRxiv : the preprint server for biology · 2025Article
- A multi-omic single-cell landscape of the aging mouse ovary.GeroScience · 2025Article
- Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.GeroScience · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system plays a major role in maintaining many physiological processes in the reproductive system. However, a complete characterization of the immune milieu in the ovary, and particularly how it is affected by female aging, is still lacking. Here, we utilize single-cell RNA sequencing and flow cytometry to construct the complete description of the murine ovarian immune system. We show that the composition of the immune cells undergoes an extensive shift with age towards adaptive immunity. We analyze the effect of aging on gene expression and chemokine and cytokine networks and show an overall decreased expression of inflammatory mediators together with an increased expression of senescent cells recognition receptors. Our results suggest that the fertile female's ovarian immune aging differs from the suggested female post-menopause inflammaging as it copes with the inflammatory stimulations during repeated cycles and the increasing need for clearance of accumulating atretic follicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.