Evidence map›Paper›PMID 37096434›Full record

ReviewThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2023

[Brain-Gut-Microbiota Axis].

Ayoung Lee, Ju Yup Lee, Sung Won Jung, Seung Yong Shin, Han Seung Ryu, Seung-Ho Jang, Joong Goo Kwon, Yong Sung Kim

Open access · goldAbstract readEnglish AbstractReview
In one paragraph

Review in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 14 citations in OpenAlex.

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  11. BTVT ameliorates offspring bloodZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Ayoung LeeDepartment of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
Ju Yup LeeDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Sung Won JungCatholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
Seung Yong ShinDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Han Seung RyuDepartment of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Korea.
Seung-Ho JangDepartment of Psychiatry, School of Medicine, Wonkwang University, Iksan, Korea.
Joong Goo KwonDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
Yong Sung KimDigestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea.ORCID 0000-0001-8836-4818
Wonkwang University · KRCatholic Kwandong University International St. Mary's Hospital · KRChung-Ang University · KRDaegu Catholic University · KRKeimyung University · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients frequently report that stress causes or exacerbates gastrointestinal (GI) symptoms, indicating a functional relationship between the brain and the GI tract. The brain and GI tract are closely related embryologically and functionally, interacting in various ways. The concept of the brain-gut axis was originally established in the 19th and early 20th centuries based on physiological observations and experiments conducted in animals and humans. In recent years, with the growing recognition that gut microbiota plays a vital role in human health and disease, this concept has been expanded to the brain-gut-microbiota axis. The brain influences the motility, secretion, and immunity of the GI tract, with consequent effects on the composition and function of the gut microbiota. On the other hand, gut microbiota plays an essential role in the development and function of the brain and enteric nervous system. Although knowledge of the mechanisms through which the gut microbiota influences distant brain function is incomplete, studies have demonstrated communication between these organs through the neuronal, immune, and endocrine systems. The brain-gut-microbiota axis is an essential aspect of the pathophysiology of functional GI disorders such as irritable bowel syndrome, and is also involved in other GI diseases, including inflammatory bowel disease. This review summarizes the evolving concept of the brain-gut-microbiota axis and its implications for GI diseases, providing clinicians with new knowledge to apply in clinical practice.

Indexed as

Gastrointestinal DiseasesMicrobiotaAnimalsBrainBrain-Gut AxisHumansBrain-gut axisInflammatory bowel diseasesIrritable bowel syndromeMicrobiotaPhysiopathology

Identifiers

PMID37096434
PMCPMC12094008
OpenAlexW4366988013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.