Evidence map›Paper›PMID 37096346›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.

Rongxiang Tang, Jeremy A Elman, Anders M Dale, Stephen M Dorros, Lisa T Eyler, Christine Fennema-Notestine, Daniel E Gustavson, Donald J Hagler, Michael J Lyons, Matthew S Panizzon and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Rongxiang TangDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-0406-9024
Jeremy A ElmanDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Anders M DaleDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Stephen M DorrosDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Daniel E GustavsonInstitute for Behavior Genetics, University of Colorado Boulder, Boulder, Colorado, USA.
Donald J HaglerDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Olivia K PuckettDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Chandra A ReynoldsDepartment of Psychology, University of California Riverside, Riverside, California, USA.ORCID 0000-0001-6502-7173
Carol E FranzDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-8629-5609
University of California San Diego · USBoston University · USUniversity of California, Riverside · USUniversity of Colorado Boulder · US

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2018 to 2022
$11.5M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
NIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838
6 · The paper itself

Abstract

backgroundChildhood disadvantage is a prominent risk factor for cognitive and brain aging. Childhood disadvantage is associated with poorer episodic memory in late midlife and functional and structural brain abnormalities in the default mode network (DMN). Although age-related changes in DMN are associated with episodic memory declines in older adults, it remains unclear if childhood disadvantage has an enduring impact on this later-life brain-cognition relationship earlier in the aging process. Here, within the DMN, we examined whether its cortical microstructural integrity-an early marker of structural vulnerability that increases the risk for future cognitive decline and neurodegeneration-is associated with episodic memory in adults at ages 56-66, and whether childhood disadvantage moderates this association.

methodsCortical mean diffusivity (MD) obtained from diffusion magnetic resonance imaging was used to measure microstructural integrity in 350 community-dwelling men. We examined both visual and verbal episodic memory in relation to DMN MD and divided participants into disadvantaged and nondisadvantaged groups based on parental education and occupation.

resultsHigher DMN MD was associated with poorer visual memory but not verbal memory (β = -0.11, p = .040 vs β = -0.04, p = .535). This association was moderated by childhood disadvantage and was significant only in the disadvantaged group (β = -0.26, p = .002 vs β = -0.00, p = .957).

conclusionsLower DMN cortical microstructural integrity may reflect visual memory vulnerability in cognitively normal adults earlier in the aging process. Individuals who experienced childhood disadvantage manifested greater vulnerability to cortical microstructure-related visual memory dysfunction than their nondisadvantaged counterparts who exhibited resilience in the face of low cortical microstructural integrity.

Indexed as

Default Mode NetworkMemory, EpisodicAgedAgingBrainChildHumansMagnetic Resonance ImagingMaleEpisodic memoryMean diffusivityNeurodegenerationSocioeconomic status

Identifiers

PMID37096346
PMCPMC11491750
OpenAlexW4366988769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.