ArticleJournal of Korean medical science2023
Gender Difference of Blood Pressure Control Rate and Clinical Prognosis in Patients With Resistant Hypertension: Real-World Observation Study.
Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Triglyceride-glucose index and systemic immune-inflammation index are associated with left ventricular hypertrophy in type 2 diabetes mellitus patients.BMC endocrine disorders · 2026Article
- Older females with late-onset hypertension are at higher CKD risk than males.Clinical kidney journal · 2026Article
- Association of leisure-time aerobic physical activity time with apparent treatment-resistant hypertension: a study based on NHANES database.Biology of sport · 2025Article
- Article
- Prevalence, Clinical Characteristics, and Treatment of Patients with Resistant Hypertension: A Single-Center Study.Journal of cardiovascular development and disease · 2024Article
- Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024Article
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundThere are several differences in the clinical course of hypertension due to the biological and social differences between men and women. Resistant hypertension is an advanced disease state, and significant gender difference could be expected, but much has not been revealed yet. The purpose of this study was to compare gender differences on the current status of blood pressure (BP) control and clinical prognosis in patients with resistant hypertension.
methodsThis is a multicenter, retrospective cohort study using common data model databases of 3 tertiary hospitals in Korea. Total 4,926 patients with resistant hypertension were selected from January 2017 to December 2018. Occurrence of dialysis, heart failure (HF) hospitalization, myocardial infarction, stroke, dementia or all-cause mortality was followed up for 3 years.
resultsMale patients with resistant hypertension were younger but had a higher cardiovascular risk than female patients. Prevalence of left ventricular hypertrophy and proteinuria was higher in men than in women. On-treatment diastolic BP was lower in women than in men and target BP achievement rate was higher in women than in men. During 3 years, the incidence of dialysis and myocardial infarction was higher in men, and the incidence of stroke and dementia was higher in women. After adjustment, male sex was an independent risk factor for HF hospitalization, myocardial infarction, and all-cause death.
conclusionIn resistant hypertension, men were younger than women, but end-organ damage was more common and the risk of cardiovascular event was higher. More intensive cardiovascular prevention strategies may be required in male patients with resistant hypertension.
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