Evidence map›Paper›PMID 37095601›Full record

Trial reportJournal of Crohn's & colitis2023

A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.

Natasha Haskey, Mehrbod Estaki, Jiayu Ye, Rachel K Shim, Sunny Singh, Levinus A Dieleman, Kevan Jacobson, Deanna L Gibson

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Crohn's & colitis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 10 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 10 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Mediterranean diet in treatment of inflammatory bowel disease: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Review
  12. Dietary Patterns and Food Choices of Adults With Inflammatory Bowel Disease in New Zealand.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Natasha HaskeyDepartment of Biology, Irving K Barber Faculty of Science, University of British Columbia-Okanagan, Kelowna, BC, Canada.
Mehrbod EstakiDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0003-4556-8444
Jiayu YeDiabetes Center, University of California San Francisco, San Francisco, CA, USA.
Rachel K ShimDepartment of Public Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Sunny SinghDivision of Gastroenterology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Levinus A DielemanDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Kevan JacobsonDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition and British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7269-8557
Deanna L GibsonDepartment of Biology, Irving K Barber Faculty of Science, University of British Columbia-Okanagan, Kelowna, BC, Canada.ORCID 0000-0003-0052-7550
University of British Columbia · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of California, San Francisco · USUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

BACKGROUND AND

aimsDietary patterns are important in managing ulcerative colitis [UC], given their influence on gut microbiome-host symbiosis and inflammation. We investigated whether the Mediterranean Diet Pattern [MDP] vs the Canadian Habitual Diet Pattern [CHD] would affect disease activity, inflammation, and the gut microbiome in patients with quiescent UC.

methodsWe performed a prospective, randomised, controlled trial in adults [65% female; median age 47 years] with quiescent UC in an outpatient setting from 2017 to 2021. Participants were randomised to an MDP [n = 15] or CHD [n = 13] for 12 weeks. Disease activity [Simple Clinical Colitis Activity Index] and faecal calprotectin [FC] were measured at baseline and week 12. Stool samples were analysed by 16S rRNA gene amplicon sequencing.

resultsThe diet was well tolerated by the MDP group. At week 12, 75% [9/12] of participants in the CHD had an FC >100 μg/g, vs 20% [3/15] of participants in the MDP group. The MDP group had higher levels of total faecal short chain fatty acids [SCFAs] [p = 0.01], acetic acid [p = 0.03], and butyric acid [p = 0.03] compared with the CHD. Furthermore, the MDP induced alterations in microbial species associated with a protective role in colitis [Alistipes finegoldii and Flavonifractor plautii], as well as the production of SCFAs [Ruminococcus bromii].

conclusionsAn MDP induces gut microbiome alterations associated with the maintenance of clinical remission and reduced FC in patients with quiescent UC. The data support that the MDP is a sustainable diet pattern that could be recommended as a maintenance diet and adjunctive therapy for UC patients in clinical remission. ClinicalTrials.gov no: NCT0305371.

Indexed as

Colitis, UlcerativeDiet, MediterraneanAdultButyric AcidCanadaFecesFemaleHumansInflammationLeukocyte L1 Antigen ComplexMaleMiddle AgedProspective StudiesRNA, Ribosomal, 16SButyric AcidLeukocyte L1 Antigen ComplexRNA, Ribosomal, 16SinflammationMediterranean dietmicrobiomeulcerative colitis

Identifiers

PMID37095601
PMCPMC10637046
OpenAlexW4366989742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.