ArticleDiabetology & metabolic syndrome2023
Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Association of polycystic ovary syndrome with metabolic syndrome and its components in adolescents: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Dietary Approaches to Stop Hypertension Diet Pattern and Metabolic Syndrome Prevalence Among U.S. Young Adults: Cross-Sectional Study From the NHANES 2011-2018.Health science reports · 2026Article
- Frequency of Low HDL Cholesterol and the Dose-Dependent Risk of Type 2 Diabetes: A Longitudinal Cohort Study.Journal of lipid and atherosclerosis · 2026Article
- Is Insulin Resistance the Driver or the Outcome of Diabetes Mellitus? A Critical Review.Journal of nutrition and metabolism · 2026Review
- Factors influencing health-promoting lifestyles in young and middle-aged adults with metabolic risk factors: a network analysis.BMC public health · 2025Article
- Cardiometabolic Phenotypes and Dietary Patterns in Albanian University-Enrolled Young Adults: Cross-Sectional Findings from theNutrients · 2025Article
- Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese.Lipids in health and disease · 2025Article
- Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review.World journal of clinical pediatrics · 2024Review
- Physiologic Effects of Isolated or Synthetic Dietary Fiber in Children: A Scoping Review.Current developments in nutrition · 2024Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults.
methodsData of 1,376,540 participants aged 20-39 years without a history of type 2 diabetes and who underwent four annual health check-ups were collected. In this large-scale prospective cohort study, we evaluated the incidence rates and hazard ratios (HRs) of diabetes according to cumulative frequencies of metabolic syndrome over 4 years of consecutive annual health check-ups (burden score 0-4). Subgroup analyses were performed by sex and age.
resultsDuring 5.18 years of follow-up, 18,155 young adults developed type 2 diabetes. The incidence of type 2 diabetes increased with burden score (P < 0.0001). The multivariable-adjusted HRs for type 2 diabetes were 4.757, 10.511, 18.288, and 31.749 in participants with a burden score of 1 to 4, respectively, compared to those with 0. In subgroup analyses, the risk of incident diabetes was greater in women than men and in the 20-29 years age group than the 30-39 years age group. The HRs were 47.473 in women and 27.852 in men with four burden scores.
conclusionThe risk of type 2 diabetes significantly increased with an increase in the cumulative burden of metabolic syndrome in young adults. Additionally, the association between cumulative burden and diabetes risk was stronger in women and the 20s age group.
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