Evidence map›Paper›PMID 37095472›Full record

SynthesisBMC ophthalmology2023

Meta-analysis of corneal endothelial changes after phacoemulsification in diabetic and non-diabetic patients.

Yingqin Yang, Hongtao Chai, Zhixiang Ding, Chengye Tang, Yongshun Liang, Yihong Li, Hao Liang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Observational
  4. Article
  5. Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yingqin YangDepartment of Ophtalmology, The First Affiliated Hospital of Guangxi Medical University, NanNing, 530000, China.
Hongtao ChaiDepartment of Gastroenterology, Affiliated Hospital of Guilin Medical University, Ginlin, 541001, China.
Zhixiang DingDepartment of Ophtalmology, Affiliated Hospital of Guilin Medical University, Ginlin, 541001, China.
Chengye TangDepartment of Ophtalmology, The First Affiliated Hospital of Guangxi Medical University, NanNing, 530000, China.
Yongshun LiangDepartment of Ophtalmology, The First Affiliated Hospital of Guangxi Medical University, NanNing, 530000, China.
Yihong LiDepartment of Ophtalmology, The First Affiliated Hospital of Guangxi Medical University, NanNing, 530000, China.
Hao LiangDepartment of Ophtalmology, The First Affiliated Hospital of Guangxi Medical University, NanNing, 530000, China. liangh@stu.gxmu.edu.cn.
Guangxi Medical University · CNFirst Affiliated Hospital of GuangXi Medical University · CNGuilin Medical University · CN

Funding

National Natural Science Foundation of China 81960174
6 · The paper itself

Abstract

backgroundCurrently, there is still controversy about the differential changes in corneal endothelium function and morphology after phacoemulsification between Diabetes Mellitus (DM) and non-Diabetes Mellitus (non-DM) patients. In this study, we aimed to evaluate the influence of phacoemulsification on the corneal endothelium in DM and non-DM patients.

methodsDatabases of PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies published between January 1, 2011 and December 25, 2021. The weighted mean difference and 95% confidence interval were used to estimate the outcomes of statistical analyses performed.

resultsThirteen studies involving 1744 eyes were included in this meta-analysis. No significant difference was observed in the central corneal thickness (CCT), endothelial cell density (ECD), coefficients of variation (CV), or hexagonal cell percentage (HCP) between the DM and non-DM groups (CCT: P = 0.91; ECD: P = 0.07; CV: P = 0.06; HCP: P = 0.09) preoperatively. The CCT was significantly thicker in the DM group at 1 month (P = 0.003) and 3 months (P = 0.0009) postoperatively, and there was no significant difference at 6 months postoperatively (P = 0.26) than non-DM group. The CV was significantly higher and HCP was significantly lower in the DM group at 1 month (CV:P < 0.0001, HCP: P = 0.002), with no significant difference at 3 months (CV: P = 0.09, HCP: P = 0.36) and 6 months (CV: P = 0.32, HCP: P = 0.36) postoperatively than non-DM group. DM patients had lower ECD than non-DM patients at all postoperative time points (1 month, 3 months: P < 0.00001, 6 months: P < 0.0001).

conclusionsThe influence of phacoemulsification on corneal endothelial damage is greater in diabetic patients. Moreover, the recovery of corneal endothelial function and morphology is delayed in these patients. Clinicians should be more attentive to the corneal health of DM patients when considering phacoemulsification.

Indexed as

Cataract ExtractionDiabetes MellitusPhacoemulsificationCell CountCorneaEndothelium, CornealHumansLens Implantation, IntraocularCorneaDiabeticMeta-analysisPhacoemulsification

Identifiers

PMID37095472
PMCPMC10124059
OpenAlexW4366829040

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.