Evidence map›Paper›PMID 37095423›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2023

Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer.

Xue Qu, Yu-Xia Cao, Yuan-Xin Xing, Qi Liu, Huan-Jie Li, Wei-Hua Yang, Ban-Qin Wang, Shu-Yi Han, Yun-Shan Wang

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xue Qu *Shandong First Medical University, No. 6699, Qingdao Road, Huaiyin District, Jinan, 250117, Shandong, China.
Yu-Xia Cao *Medical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, 250013, Shandong, China.
Yuan-Xin XingResearch Center of Basic Medicine, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, 250013, Shandong, China.
Qi LiuShandong University, No. 44, Wenhua West Road, Jinan, 250100, Shandong, China.
Huan-Jie LiMedical Integration and Practice Center, Shandong University, Jinan, China.
Wei-Hua YangMedical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, 250013, Shandong, China.
Ban-Qin WangDepartment of Blood Transfusion, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China. 3052@sdhospital.com.cn.
Shu-Yi HanMedical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, 250013, Shandong, China. hanshuyi2016@126.com.ORCID http://orcid.org/0000-0002-4246-292X
Yun-Shan WangMedical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, 250013, Shandong, China.
Jinan Central Hospital · CNShandong University · CNShandong First Medical University · CNShandong Provincial QianFoShan Hospital · CN

Funding

Academic promotion program of Shandong First Medical University 2019QL024Jinan Clinical Medical Science and Technology Innovation Project 202019034Multi center clinical application research of biological high-performance computing in precision medicine YCZYPT(2022)-04-05Natural Science Foundation of Shandong Province ZR2020MH320
6 · The paper itself

Abstract

The mechanism of deleted in lymphocytic leukemia 2 (DLEU2)-long non-coding RNA in tumors has become a major point of interest in recent research related to the occurrence and development of a variety of tumors. Recent studies have shown that the long non-coding RNA DLEU2 (lncRNA-DLEU2) can cause abnormal gene or protein expression by acting on downstream targets in cancers. At present, most lncRNA-DLEU2 play the role of oncogenes in different tumors, which are mostly associated with tumor characteristics, such as proliferation, migration, invasion, and apoptosis. The data thus far show that because lncRNA-DLEU2 plays an important role in most tumors, targeting abnormal lncRNA-DLEU2 may be an effective treatment strategy for early diagnosis and improving the prognosis of patients. In this review, we integrated lncRNA-DLEU2 expression in tumors, its biological functions, molecular mechanisms, and the utility of DLEU2 as an effective diagnostic and prognostic marker of tumors. This study aimed to provide a potential direction for the diagnosis, prognosis, and treatment of tumors using lncRNA-DLEU2 as a biomarker and therapeutic target.

Indexed as

Leukemia, LymphoidMicroRNAsRNA, Long NoncodingBiomarkersCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansBiomarkersDLEU1 lncRNA, humanMicroRNAsRNA, Long NoncodingBiomarkerCancerFunctionslncRNA-DLEU2Molecular mechanisms

Identifiers

PMID37095423
PMCPMC10462543
OpenAlexW4366824556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.