Evidence map›Paper›PMID 37095252›Full record

ReviewNature reviews. Endocrinology2023

Adrenal cysts: an emerging condition.

Jan Calissendorff, C Christofer Juhlin, Anders Sundin, Irina Bancos, Henrik Falhammar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Adrenal Pseudocyst Masquerading as Adrenocortical Carcinoma.Clinical medicine insights. Endocrinology and diabetes · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Adrenal Cysts: To Operate or Not to Operate?Journal of clinical medicine · 2024
    Review
  14. Article
  15. Article
  16. Cystic pheochromocytoma.Oxford medical case reports · 2023
    Article
  17. Specialty grand challenge in adrenal endocrinology.Frontiers in endocrinology · 2023
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jan CalissendorffDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-2088-5814
C Christofer JuhlinDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-5945-9081
Anders SundinDepartment of Surgical Sciences, Radiology & Molecular Imaging, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-2214-6217
Irina BancosDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9332-2524
Henrik FalhammarDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden. henrik.falhammar@ki.se.ORCID 0000-0002-5622-6987
Karolinska University Hospital · SEMayo Clinic in Arizona · USUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenal cysts are rare lesions representing approximately 1-2% of adrenal incidentalomas. The majority of these rare lesions are benign. Rarely, phaeochromocytomas and adrenal malignant masses can present as cystic lesions and can occasionally be difficult to distinguish from benign cysts. Histologically, adrenal cysts are subdivided into pseudocysts, endothelial cysts, epithelial cysts and parasitic cysts. The radiological appearance of an adrenal cyst is generally similar to that of cysts in the kidney. They are thus well demarcated, usually rounded, with a thin wall and homogenous internal structure, low attenuating (<20 Hounsfield Units) on CT, low signalling on T1-weighted MRI sequences and high signalling on T2-weighted MRI sequences, and anechoic or hypoechoic on ultrasonography. Benign adrenal cysts have a slight female predominance and are usually diagnosed between the ages of 40 and 60. Most adrenal cysts are asymptomatic and are detected incidentally, although very large adrenal cysts can lead to mass effect symptoms, with surgery required to alleviate the symptoms. Thus, conservative management is usually recommended for asymptomatic cysts. However, when uncertainty exists regarding the benign nature of the cyst, additional work-up or follow-up is needed. The management of an adrenal cyst should preferably be discussed at an adrenal multidisciplinary team meeting.

Indexed as

Adrenal Gland DiseasesAdrenal Gland NeoplasmsCystsPheochromocytomaAdultDiagnosis, DifferentialFemaleHumansMaleMiddle AgedTomography, X-Ray Computed

Identifiers

PMID37095252
OpenAlexW4366826339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.