ArticleNature medicine2023
A shared neural basis underlying psychiatric comorbidity.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Executive functions as a transdiagnostic endophenotype in developmental psychopathology.Molecular psychiatry · 2026Review
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
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- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- A longitudinal resource for mapping interindividual variation in the aging connectome.Scientific data · 2026Article
- Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies.Molecular psychiatry · 2026Review
- The impact of rejection sensitivity on suicidal ideation among college students: the role of social connectedness and negative affect.Scientific reports · 2026Article
- Who gets included? Equity in digital and decentralised mental health and neurodevelopmental trials: A systematic review.PLOS digital health · 2026Article
- Risk of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in Children With Hypoxic-Ischemic Encephalopathy.Journal of autism and developmental disorders · 2026Article
- The association between maternal and paternal parenting styles and adolescents' overall mental problem: a longitudinal study.BMC psychology · 2026Article
- Machine-Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Development and Psychometric Evaluation of the Scale of Externalizing Problem Behaviors in Adults (SEPBA): A Hybrid Dimensional-Categorical Instrument.Actas espanolas de psiquiatria · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.Nature communications · 2026Article
- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- Association between breakfast frequency, community space environment, and psychological symptoms: a cross-sectional study of Chinese adolescents.Frontiers in psychology · 2026Article
- Sustained breastfeeding associations with brain structure and cognition from late childhood to early adolescence.Pediatric research · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
51 authors at 20 institutions in 7 countries.
Chao XieInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Shitong XiangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-5513-4714
Chun ShenInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Xuerui PengFaculty of Psychology, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-8780-0910
Jujiao KangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Yuzhu LiInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Wei ChengInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Shiqi HeInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Marina BobouSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
M John BroulidakisClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Betteke Maria van NoortDepartment of Psychology, MSB Medical School Berlin, Berlin, Germany.
Zuo ZhangSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Lauren RobinsonDepartment of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nilakshi VaidyaDepartment of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jeanne WintererDepartment of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Yuning ZhangPsychology Department, University of Southampton, Southampton, UK.
Sinead KingSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Antoine GrigisNeuroSpin, C.E.A., Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Hervé LemaîtreInstitut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, France.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales en psychiatrie', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales en psychiatrie', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, C.E.A., Université Paris-Saclay, Gif-sur-Yvette, France.
Tomáš PausDepartment of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Quebec, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Ulrike SchmidtDepartment of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Julia SinclairClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Argyris StringarisDivision of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, UK.
Henrik WalterDepartment of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Barbara J SahakianInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Trevor W Robbins *Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Gunter Schumann *Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Tianye Jia *Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. tianyejia@fudan.edu.cn.
Jianfeng Feng *Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
IMAGEN Consortium
STRATIFY/ESTRA Consortium
ZIB Consortium
King's College London · GBFudan University · CNHumboldt-Universität zu Berlin · DECentre National de la Recherche Scientifique · FRTechnische Universität Dresden · DEUniversity of Southampton · GBHeidelberg University · DEMSB Medical School Berlin · DETrinity College Dublin · IEUniversität Hamburg · DEUniversité Paris-Saclay · FRUniversity of Cambridge · GBCentre Hospitalier Universitaire Sainte-Justine · CAPhysikalisch-Technische Bundesanstalt · DEUniversity College London · GBUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Potsdam · DEUniversity of Vermont · USZhejiang Normal University · CN
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kMedical Research Council MRF-058-0009-RG-DESR-C0759Medical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH085772
Abstract
Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.
Indexed as
Mental DisordersAdolescentComorbidityHumansNeuroimagingPsychopathologyYoung Adult
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.