Evidence map›Paper›PMID 37095237›Full record

ArticleNature chemical biology2023

Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs.

Stephanie Gu, Eric S Szymanski, Atul K Rangadurai, Honglue Shi, Bei Liu, Akanksha Manghrani, Hashim M Al-Hashimi

Abstract read
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Nature communications · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Direct Measurement of 8OGbioRxiv : the preprint server for biology · 2024
    Article
  14. DNA damage twists base choreography.Nature chemical biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Stephanie GuDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-6337-3731
Eric S SzymanskiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Atul K RangaduraiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Honglue ShiDepartment of Chemistry, Duke University, Durham, NC, USA.
Bei LiuDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Akanksha ManghraniDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. ha2639@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-0681-1747
Duke University · USColumbia University Irving Medical Center · US

Funding

Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
NIGMS NIH HHS R01 GM089846
6 · The paper itself

Abstract

Replicative errors contribute to the genetic diversity needed for evolution but in high frequency can lead to genomic instability. Here, we show that DNA dynamics determine the frequency of misincorporating the A•G mismatch, and altered dynamics explain the high frequency of 8-oxoguanine (8OG) A•8OG misincorporation. NMR measurements revealed that A

Indexed as

DNADNA DamageBase PairingHumansMutagenesisDNA

Identifiers

PMID37095237
PMCPMC13290353
OpenAlexW4366823925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.