ArticleNature plants2023
The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response.The New phytologist · 2025Review
- A nucleoporin-associated signaling cascade controls plant immunity via histone modification.Genome biology · 2025Article
- Biomolecular condensates in plant immunity.Cell host & microbe · 2025Review
- Maize leaf yellowing gene ZmCAAX modulates growth and drought resistance by regulating abscisic acid contents through interaction with the ABA biosynthetic enzyme ZmNCED3.Plant biotechnology journal · 2025Article
- Phase Separation: Orchestrating Biological Adaptations to Environmental Fluctuations.International journal of molecular sciences · 2025Review
- The Nucleoporin CPR5 Modulates Plant Immunity via Guanylate-Binding Proteins.Molecular plant pathology · 2025Article
- Structural Diversity and Distribution of Nuclear Matrix Constituent Protein Class Nuclear Lamina Proteins in Streptophytic Algae.Genome biology and evolution · 2024Article
- CRWN nuclear lamina components maintain the H3K27me3 landscape and promote successful reproduction in Arabidopsis.The New phytologist · 2024Article
- Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome.BMC biology · 2024Article
- KAKU4 regulates leaf senescence through modulation of H3K27me3 deposition in the Arabidopsis genome.BMC plant biology · 2024Article
- Evolutionarily conserved protein motifs drive interactions between the plant nucleoskeleton and nuclear pores.The Plant cell · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Guanylate binding proteins (GBPs) are prominent regulators of immunity not known to be required for nuclear envelope formation and morphogenesis. Here we identify the Arabidopsis GBP orthologue AtGBPL3 as a lamina component with essential functions in mitotic nuclear envelope reformation, nuclear morphogenesis and transcriptional repression during interphase. AtGBPL3 is preferentially expressed in mitotically active root tips, accumulates at the nuclear envelope and interacts with centromeric chromatin as well as with lamina components transcriptionally repressing pericentromeric chromatin. Reduced expression of AtGBPL3 or associated lamina components similarly altered nuclear morphology and caused overlapping transcriptional deregulation. Investigating the dynamics of AtGBPL3-GFP and other nuclear markers during mitosis (1) revealed that AtGBPL3 accumulation on the surface of daughter nuclei precedes nuclear envelope reformation and (2) uncovered defects in this process in roots of AtGBPL3 mutants, which cause programmed cell death and impair growth. AtGBPL3 functions established by these observations are unique among dynamin-family large GTPases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.