Evidence map›Paper›PMID 37095138›Full record

ArticleScientific reports2023

Evaluation of bone growth around bioactive glass S53P4 by scanning acoustic microscopy co-registered with optical interferometry and elemental analysis.

Axi Holmström, Antti Meriläinen, Jere Hyvönen, Anton Nolvi, Tuomo Ylitalo, Kari Steffen, Robert Björkenheim, Gustav Strömberg, Heikki J Nieminen, Ivan Kassamakov and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Axi HolmströmElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland. axi.holmstrom@helsinki.fi.
Antti MeriläinenElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Jere HyvönenElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Anton NolviElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Tuomo YlitaloElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Kari SteffenElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Robert BjörkenheimDepartment of Orthopaedics and Traumatology, Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Gustav StrömbergDepartment of Hand Surgery, Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Heikki J NieminenElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Ivan KassamakovElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Jukka PajarinenDepartment of Plastic Surgery, Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Leena HupaJohan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, Finland.
Ari SalmiElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Edward HæggströmElectronics Research Laboratory, Department of Physics, University of Helsinki, Helsinki, Finland.
Nina C LindforsDepartment of Hand Surgery, Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIÅbo Akademi University · FIHelsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive glass (BAG) is a bone substitute that can be used in orthopaedic surgery. Following implantation, the BAG is expected to be replaced by bone via bone growth and gradual degradation of the BAG. However, the hydroxyapatite mineral forming on BAG resembles bone mineral, not providing sufficient contrast to distinguish the two in X-ray images. In this study, we co-registered coded-excitation scanning acoustic microscopy (CESAM), scanning white light interferometry (SWLI), and scanning electron microscopy with elemental analysis (Energy Dispersive X-ray Spectroscopy) (SEM-EDX) to investigate the bone growth and BAG reactions on a micron scale in a rabbit bone ex vivo. The acoustic impedance map recorded by the CESAM provides high elasticity-associated contrast to study materials and their combinations, while simultaneously producing a topography map of the sample. The acoustic impedance map correlated with the elemental analysis from SEM-EDX. SWLI also produces a topography map, but with higher resolution than CESAM. The two topography maps (CESAM and SWLI) were in good agreement. Furthermore, using information from both maps simultaneously produced by the CESAM (acoustic impedance and topography) allowed determining regions-of-interest related to bone formation around the BAG with greater ease than from either map alone. CESAM is therefore a promising tool for evaluating the degradation of bone substitutes and the bone healing process ex vivo.

Indexed as

Bone SubstitutesMicroscopy, AcousticAnimalsGlassInterferometryMicroscopy, Electron, ScanningOsteogenesisRabbitsbioactive glass S53P4Bone Substitutes

Identifiers

PMID37095138
PMCPMC10126192
OpenAlexW4366975493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.