Evidence map›Paper›PMID 37095119›Full record

Trial reportScientific reports2023

Plasma mineral status after a six-month intervention providing one egg per day to young Malawian children: a randomized controlled trial.

Marina Perez-Plazola, Jenna Diaz, Christine P Stewart, Charles D Arnold, Bess L Caswell, Chessa K Lutter, E Rochelle Werner, Kenneth Maleta, Jay Turner, Pradeep Prathibha and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Marina Perez-PlazolaWashington University School of Medicine in St. Louis, St. Louis, USA.
Jenna DiazDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Washington University School of Medicine in St. Louis, 660 South Euclid Avenue, Campus, Box 8208, St. Louis, MO, 63110, USA. jndq39@gmail.com.
Christine P StewartInstitute for Global Nutrition, Department of Nutrition, University of California Davis, Davis, USA.
Charles D ArnoldInstitute for Global Nutrition, Department of Nutrition, University of California Davis, Davis, USA.
Bess L CaswellInstitute for Global Nutrition, Department of Nutrition, University of California Davis, Davis, USA.
Chessa K LutterInternational Development Group, RTI International US, Triangle Park, USA.
E Rochelle WernerInstitute for Global Nutrition, Department of Nutrition, University of California Davis, Davis, USA.
Kenneth MaletaSchool of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Jay TurnerDivision of Engineering Education Energy, Environmental Energy and Chemical Engineering, Washington University in St. Louis, St. Louis, USA.
Pradeep PrathibhaDivision of Engineering Education Energy, Environmental Energy and Chemical Engineering, Washington University in St. Louis, St. Louis, USA.
Xuan LiuDivision of Engineering Education Energy, Environmental Energy and Chemical Engineering, Washington University in St. Louis, St. Louis, USA.
Emmanuel GyimahInstitute for Public Health, Washington University in St. Louis, St. Louis, USA.
Lora IannottiInstitute for Public Health, Washington University in St. Louis, St. Louis, USA.
Washington University in St. Louis · USUniversity of California, Davis · USKamuzu Central Hospital · MWRTI International · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Washington University Center for Diabetes Translation Research P30DK092950 · NIDDK · WASHINGTON UNIVERSITY · PI Ross C Brownson, Debra Haire-Joshu · 2011 to 2026
$11.7M
NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK092950
6 · The paper itself

Abstract

Mineral deficiencies are common in children living in low-resource areas. Eggs are a rich source of essential nutrients and have been shown to improve growth in young children, although little is known about their impact on mineral status. Children aged 6-9 months (n = 660) were randomized to receive either one egg/day for 6-months or no intervention. Anthropometric data, dietary recalls, and venous blood were collected at baseline and 6-months follow-up. Quantification of plasma minerals (n = 387) was done using inductively coupled plasma-mass spectroscopy. Difference-in-difference mean plasma mineral concentrations was determined from baseline and follow-up values and assessed between groups by intention-to-treat using ANCOVA regression models. Prevalence of zinc deficiency was 57.4% at baseline and 60.5% at follow-up. Mean difference (MD) of plasma magnesium, selenium, copper, and zinc levels were not different between groups. Plasma iron concentrations were significantly lower in the intervention compared to the control group (MD = - 9.29; 95% CI: - 15.95, - 2.64). Zinc deficiency was widely prevalent in this population. Mineral deficiencies were not addressed with the egg intervention. Further interventions are needed to improve the mineral status of young children.

Indexed as

MalnutritionSeleniumChildChild, PreschoolCopperHumansIronZincCopperIronSeleniumZinc

Identifiers

PMID37095119
PMCPMC10125967
OpenAlexW4366823040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.