ArticleNature communications2023
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
20 citing papers in PubMed, 19 citations in OpenAlex.
- TrenibotulinumtoxinE: Pharmacology, clinical evidence, and emerging role in aesthetic medicine.JPRAS open · 2026Review
- Structural Determinants of Synaptic Vesicle Protein 2C Ligand Selectivity and Their Impact on Dopamine Release.bioRxiv : the preprint server for biology · 2026Article
- Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis.Neural regeneration research · 2026Article
- A belt-buckle checkpoint regulates the onset of botulinum neurotoxin intoxication.Nature communications · 2026Article
- A case report of atypical type E botulism.World journal of emergency medicine · 2026Article
- Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.Toxins · 2026Review
- Evaluation of a Cell-Based Potency Assay for Detection of the Potency of TrenibotulinumtoxinEToxins · 2025Article
- Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A).Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams.Nature communications · 2025Article
- Can Botulinum Toxin Type E Serve as a Novel Therapeutic Target for Managing Chronic Orofacial Pain?Toxins · 2025Article
- Article
- Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation.Nature communications · 2025Article
- An Advanced Sensing Approach to Biological Toxins with Localized Surface Plasmon Resonance Spectroscopy Based on Their Unique Protein Quaternary Structures.International journal of molecular sciences · 2024Article
- Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.Nature structural & molecular biology · 2024Article
- Embracing the Versatility of Botulinum Neurotoxins in Conventional and New Therapeutic Applications.Toxins · 2024Review
- Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil.Neuroscience bulletin · 2024Review
- Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.Nature communications · 2024Article
- SV2B/miR-34a/miR-128 axis as prognostic biomarker in glioblastoma multiforme.Scientific reports · 2024Article
- Rapid generation of high-quality structure figures for publication with PyMOL-PUB.Bioinformatics (Oxford, England) · 2024Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Zheng LiuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.ORCID 0000-0002-6842-6273
Pyung-Gang LeeDepartment of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Nadja KrezInstitute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.ORCID 0000-0003-4334-501X
Kwok-Ho LamDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.
Hao LiuDepartment of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Adina PrzykopanskiInstitute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.
Peng ChenDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.ORCID 0000-0002-6356-7683
Guorui YaoDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.
Sicai ZhangDepartment of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Jacqueline M TremblayTufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.
Kay PerryNE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, IL, 60439, USA.ORCID 0000-0002-4046-1704
Charles B ShoemakerTufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.ORCID 0000-0001-9738-1361
Andreas RummelInstitute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.ORCID 0000-0002-0645-1641
Min DongDepartment of Urology, Boston Children's Hospital, Boston, MA, 02115, USA. Min.Dong@childrens.harvard.edu.ORCID 0000-0002-1744-7293
Rongsheng JinDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA. r.jin@uci.edu.ORCID 0000-0003-0348-7363
University of California, Irvine · USBoston Children's Hospital · USMedizinische Hochschule Hannover · DENew England Disabled Sports · USArgonne National Laboratory · US
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MStructure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4MLong-term effects of botulinum neurotoxins on neuronal viabilityR01NS080833 · NINDS · HARVARD MEDICAL SCHOOL · PI Min Dong · 2013 to 2026
$6.8MDeveloping broad-spectrum therapeutics against C. difficile toxinsR01AI158503 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2025
$3.9MMolecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5MMolecular mechanisms of botulinum neurotoxin neutralizationR01AI125704 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG, SHOEMAKER, CHARLES BIX · 2016 to 2020
$3.0MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MStructural basis of Rho glucosylation by Clostridium difficile toxinsR21AI156092 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432kStructural basis for recognition of SV2 by type E botulinum neurotoxinR21AI163178 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432kStructural mechanism for recognition of host receptor by botulinum neurotoxin AR21AI123920 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2016 to 2017
$425kNIAID NIH HHS R01 AI125704NIAID NIH HHS R01 AI132387NIAID NIH HHS R01 AI139087NIAID NIH HHS R01 AI158503NIAID NIH HHS R21 AI123920NIAID NIH HHS R21 AI156092NIAID NIH HHS R21 AI163178NICHD NIH HHS P50 HD105351NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527NINDS NIH HHS R01 NS080833
Abstract
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (H
Indexed as
Botulinum Toxins, Type ASynaptic VesiclesBotulinum ToxinsHumansMembrane GlycoproteinsNerve Tissue ProteinsProtein BindingBotulinum ToxinsBotulinum Toxins, Type Abotulinum toxin type EMembrane GlycoproteinsNerve Tissue Proteins
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