Evidence map›Paper›PMID 37094933›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition.

Saurabh S Kokane, Robert D Cole, Bogdan Bordieanu, Chevin M Ray, Ishraq A Haque, James M Otis, Jacqueline F McGinty

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Prefrontal cortex excitatory neurons show distinct response to heroin-associated cue and social stimulus after prolonged heroin abstinence in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Saurabh S KokaneDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Robert D ColeDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Bogdan BordieanuDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Chevin M RayDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Ishraq A HaqueDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID 0000-0003-4199-7970
James M OtisDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Jacqueline F McGintyDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425 mcginty@musc.edu.
Medical University of South Carolina · US

Funding

Selective Restoration of KCNQ Channel Inhibition in the PFC to Inhibit Cue-InducP50DA015369 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KALIVAS, PETER W · 2003 to 2017
$18.6M
DRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8M
NIDA NIH HHS P50 DA015369NIDA NIH HHS T32 DA007288
6 · The paper itself

Abstract

Dysregulation of the input from the prefrontal cortex (PFC) to the nucleus accumbens (NAc) contributes to cue-induced opioid seeking but the heterogeneity in, and regulation of, prelimbic (PL)-PFC to NAc (PL->NAc) neurons that are altered has not been comprehensively explored. Recently, baseline and opiate withdrawal-induced differences in intrinsic excitability of Drd1

Indexed as

CocaineNucleus AccumbensAnimalsCuesCyclic AMP-Dependent Protein KinasesHeroinMaleNeuronal PlasticityNeuronsRatsRats, Long-EvansRats, Sprague-DawleyReceptors, Dopamine D2RecurrenceCocaineCyclic AMP-Dependent Protein KinasesDRD2 protein, ratHeroinReceptors, Dopamine D2abstinencedopamine receptorsexcitabilityheroinprelimbic cortexprotein kinase A

Identifiers

PMID37094933
PMCPMC10255008
OpenAlexW4366816804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.