Evidence map›Paper›PMID 37094919›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2023

National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the UK.

Katie Evans, Cheryl Battersby, James P Boardman, Elaine Boyle, Will Carroll, Kate Dinwiddy, Jon Dorling, Katie Gallagher, Pollyanna Hardy, Emma Johnston and 4 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
8.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Katie EvansSchool of Public Health, Faculty of Medicine, Neonatal Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0503-9807
Cheryl BattersbySchool of Public Health, Faculty of Medicine, Neonatal Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2898-553X
James P BoardmanNeonatal Medicine, The University of Edinburgh MRC Centre for Reproductive Health, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3904-8960
Elaine BoyleNeonatal Medicine, University of Leicester, Leicester, UK.
Will CarrollChild Health, Keele University, Keele, UK.ORCID http://orcid.org/0000-0003-2742-1836
Kate DinwiddyBritish Association of Perinatal Medicine, London, UK.
Jon DorlingDepartment of Neonatal Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Katie GallagherEGA Institute for Women's Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-6847-9594
Pollyanna HardyPolicy Research Unit in Maternal Health & Care, National Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Emma JohnstonParents and Family Engagement Lead, Thames Valley and Wessex Operational Delivery Network, Thames Valley and Wessex, UK.
Helen MactierNeonatal Medicine, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-6154-5758
Claire MarcroftNeonatal Physiotherapy, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
James William Harrison WebbeSchool of Public Health, Faculty of Medicine, Neonatal Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-8546-3212
Chris GaleSchool of Public Health, Faculty of Medicine, Neonatal Medicine, Imperial College London, London, UK christopher.gale@imperial.ac.uk.ORCID http://orcid.org/0000-0003-0707-876X
Imperial College London · GBKeele University · GBMRC Centre for Reproductive Health · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBThames Valley Hospital · GBUniversity College London · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Glasgow · GBUniversity of Leicester · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/V036866/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThe provision of neonatal care is variable and commonly lacks adequate evidence base; strategic development of methodologically robust clinical trials is needed to improve outcomes and maximise research resources. Historically, neonatal research topics have been selected by researchers; prioritisation processes involving wider stakeholder groups have generally identified research themes rather than specific questions amenable to interventional trials.

objectiveTo involve stakeholders including parents, healthcare professionals and researchers to identify and prioritise research questions suitable for answering in neonatal interventional trials in the UK.

designResearch questions were submitted by stakeholders in population, intervention, comparison, outcome format through an online platform. Questions were reviewed by a representative steering group; duplicates and previously answered questions were removed. Eligible questions were entered into a three-round online Delphi survey for prioritisation by all stakeholder groups.

participantsOne hundred and eight respondents submitted research questions for consideration; 144 participants completed round one of the Delphi survey, 106 completed all three rounds.

resultsTwo hundred and sixty-five research questions were submitted and after steering group review, 186 entered into the Delphi survey. The top five ranked research questions related to breast milk fortification, intact cord resuscitation, timing of surgical intervention in necrotising enterocolitis, therapeutic hypothermia for mild hypoxic ischaemic encephalopathy and non-invasive respiratory support.

conclusionsWe have identified and prioritised research questions suitable for practice-changing interventional trials in neonatal medicine in the UK at the present time. Trials targeting these uncertainties have potential to reduce research waste and improve neonatal care.

Indexed as

Health PersonnelHealth PrioritiesDelphi TechniqueFemaleHumansInfant, NewbornRandomized Controlled Trials as TopicResearch DesignUnited Kingdomhealth services researchneonatology

Identifiers

PMID37094919
PMCPMC10646876
OpenAlexW4366819596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.