Evidence map›Paper›PMID 37094384›Full record

ArticleJournal of biomechanics2023

A two-dimensional finite element model of intercellular cAMP signaling through gap junction channels.

P Dunn, N S Annamdevula, S J Leavesley, T C Rich, A-V Phan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

P DunnDepartment of Mechanical, Aerospace and Biomedical Engineering, University of South Alabama, Mobile, AL 36688, USA.
N S AnnamdevulaCenter for Lung Biology & Department of Pharmacology University of South Alabama, Mobile, AL 36688, USA.
S J LeavesleyCenter for Lung Biology & Department of Pharmacology University of South Alabama, Mobile, AL 36688, USA; Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile, AL 36688, USA.
T C RichCenter for Lung Biology & Department of Pharmacology University of South Alabama, Mobile, AL 36688, USA.
A-V PhanDepartment of Mechanical, Aerospace and Biomedical Engineering, University of South Alabama, Mobile, AL 36688, USA. Electronic address: vphan@southalabama.edu.
University of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6M
G Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3M
Request for a Spectral Confocal MicroscopeS10RR027535 · NCRR · UNIVERSITY OF SOUTH ALABAMA · PI RICH, THOMAS C · 2010 to 2010
$397k
Andor Revolution WD Confocal Imaging SystemS10OD020149 · OD · UNIVERSITY OF SOUTH ALABAMA · PI TAYLOR, MARK STEPHEN · 2015 to 2015
$395k
NCRR NIH HHS S10 RR027535NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL058506NIH HHS S10 OD020149
6 · The paper itself

Abstract

While cyclic adenosine monophosphate (cAMP) is typically considered an intracellular signal, it has been shown to spread between adjacent cells through connexin-based gap junction channels, promoting gap junctional intercellular communication (GJIC). Gap junction-mediated signaling is critical for the coordinated function of many tissues, and have been linked with cardiovascular disease, neurogenerative disease, and cancers. In particular, it plays a complex role in tumor suppression or promotion. This work introduces a two-dimensional finite element model that can describe intercellular cAMP signaling in the presence of gap junctions on membrane interfaces. The model was utilized to simulate cAMP transfer through one and two gap junction channels on the interface of a cluster of two pulmonary microvascular endothelial cells. The simulation results were found to generally agree with what has been observed in the literature in terms of GJIC. The research outcomes suggest that the proposed model can be employed to evaluate the permeability properties of a gap junction channel if its cAMP volumetric flow rate can be experimentally measured.

Indexed as

Endothelial CellsGap JunctionsCell CommunicationConnexinsCyclic AMPFinite Element AnalysisConnexinsCyclic AMPEndothelial cellsFinite element analysisIntercellular cAMP signalingPulmonary vasculatureSecond messenger signals

Identifiers

PMID37094384
PMCPMC10173664
OpenAlexW4366256899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.