ArticleEuropean biophysics journal : EBJ1986
The human erythrocyte membrane skeleton may be an ionic gel. I. Membrane mechanochemical properties.
Article in European biophysics journal : EBJ, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Energy Dissipation in the Human Red Cell Membrane.Biomolecules · 2023Article
- On the Role of Curved Membrane Nanodomains, and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding.International journal of molecular sciences · 2021Article
- A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation.Biomechanics and modeling in mechanobiology · 2016Article
- Systems biology and physical biology of clathrin-mediated endocytosis.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Attachment of beta 2-glycoprotein I to negatively charged liposomes may prevent the release of daughter vesicles from the parent membrane.European biophysics journal : EBJ · 2008Article
- Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model.Molecular physics · 2008Article
- Amphiphile-induced tubular budding of the bilayer membrane.European biophysics journal : EBJ · 2005Article
- Shape memory of human red blood cells.Biophysical journal · 2004Article
- Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding.Biophysical journal · 2001Article
- Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study.Biophysical journal · 1999Article
- Direct measures of large, anisotropic strains in deformation of the erythrocyte cytoskeleton.Biophysical journal · 1999Article
- Simulations of the erythrocyte cytoskeleton at large deformation. I. Microscopic models.Biophysical journal · 1998Article
- Influence of network topology on the elasticity of the red blood cell membrane skeleton.Biophysical journal · 1997Article
- Kinematics of red cell aspiration by fluorescence-imaged microdeformation.Biophysical journal · 1996Article
- A tethered adhesive particle model of two-dimensional elasticity and its application to the erythrocyte membrane.Biophysical journal · 1996Article
- An elastic network model based on the structure of the red blood cell membrane skeleton.Biophysical journal · 1996Article
- Shapes of bilayer vesicles with membrane embedded molecules.European biophysics journal : EBJ · 1996Article
- Measurement of erythrocyte membrane elasticity by flicker eigenmode decomposition.Biophysical journal · 1995Article
- Depletion of membrane skeleton in red blood cell vesicles.Biophysical journal · 1995Article
- Bending stiffness of lipid bilayers: IV. Interpretation of red cell shape change.Biophysical journal · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biochemical and biophysical observations indicate that the erythrocyte membrane skeleton is composed of a swollen network of long, flexible and ionizable macromolecules located at the cytoplasmic surface of the fluid membrane lipid bilayer. We have analyzed the mechanochemical properties of the erythrocyte membrane assuming that the membrane skeleton constitutes an ionic gel (swollen ionic elastomer). Using recently established statistical thermodynamic theory for such gels, our analysis yields mathematical expressions for the mechanochemical properties of erythrocyte membranes that incorporate membrane molecular parameters to an extent not achieved previously. The erythrocyte membrane elastic shear modulus and maximum elastic extension ratio predicted by our membrane model are in quantitative agreement with reported values for these parameters. The gel theory predicts further that the membrane skeleton modulus of area compression, KG, may be small as well as large relative to the membrane elastic shear modulus, G, depending on the environmental conditions. Our analysis shows that the ratio between these two parameters affects both the geometry and the stability of the favoured cell shapes.
Indexed as
Identifiers
3709419What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.