Evidence map›Paper›PMID 37094160›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

SRC2 controls CD4

Wencan Zhang, Xu Cao, Xiancai Zhong, Hongmin Wu, Yun Shi, Mingye Feng, Yi-Chang Wang, David Ann, Yousang Gwack, Yate-Ching Yuan and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. ETV1 Drives CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Unfolded protein responses in T cell immunity.Frontiers in immunology · 2024
    Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Wencan ZhangDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.ORCID 0000-0002-8828-2000
Xu CaoDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010.ORCID 0000-0002-9927-6802
Xiancai ZhongDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.ORCID 0000-0001-8312-4057
Hongmin WuDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
Yun ShiDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
Mingye FengDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
Yi-Chang WangDepartment of Diabetes Complication and Metabolism, Arthur Rigs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
David AnnDepartment of Diabetes Complication and Metabolism, Arthur Rigs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0002-2821-9245
Yate-Ching YuanDivision of Translational Bioinformatic, Bioinformatics Core, City of Hope, Duarte, CA 91010.ORCID 0000-0002-3698-9784
Weirong ShangDepartment of Gynecology and Obsterics, School of Medicine, Emory University, Atlanta, GA 30322.ORCID 0000-0002-7993-9138
Zuoming SunDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010.ORCID 0000-0003-1896-6666
City of Hope · USCity Of Hope National Medical Center · USEmory University · USUniversity of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Steroid nuclear receptor coactivators in T cell differentiationR01AI109644 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zuoming Sun · 2014 to 2026
$6.9M
Function of TCF-1 in antagonizing malignancyR21AI163256 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SUN, ZUOMING · 2021 to 2022
$484k
NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA033572NIAID NIH HHS R01 AI109644NIAID NIH HHS R21 AI163256
6 · The paper itself

Abstract

T cell activation stimulates substantially increased protein synthesis activity to accumulate sufficient biomass for cell proliferation. The protein synthesis is fueled by the amino acids transported from the environment. Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. Here, we show that SRC2 recruited by c-Myc enhances CD4

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalT-LymphocytesAnimalsCD4-Positive T-LymphocytesCytokinesMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Coactivator 2Up-RegulationCytokinesNcoa2 protein, mouseNuclear Receptor Coactivator 2autoimmunityCD4+ T cellc-MycT cell activation

Identifiers

PMID37094160
PMCPMC10160970
OpenAlexW4366816318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.