ArticleProceedings of the National Academy of Sciences of the United States of America2023
High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Neurobiological insights into the effects of ultra-processed food on lipid metabolism and associated mental health conditions: a scoping review.Frontiers in nutrition · 2025Pooled it
- Moderate Food Preferences and Depression with Grey Matter as a Potential Mediator: A Large-Scale Longitudinal Study.Foods (Basel, Switzerland) · 2026Article
- Aspirin alleviates long-term high-fat diet-induced depressive-like behavior in male mice via suppressing arachidonic acid-mediated microglial activation and neuroinflammation.Molecular psychiatry · 2026Article
- Joint effects of depression, lipid metabolic dysfunction, and their trajectories on incident cardiometabolic multimorbidity: a prospective multi-cohort analysis from two national cohorts.Lipids in health and disease · 2026Article
- Psychosocial Burden, Multi-System Somatic Symptom Severity, and Weight-Related Stigma in Late Adolescents and Young Adults: A Cross-Sectional Survey from Romania.Life (Basel, Switzerland) · 2026Article
- Microplastics Decrease the Toxicity ofToxics · 2026Article
- Single-cell transcriptome-wide Mendelian randomization during CD4Communications biology · 2026Article
- A multi-omics analysis of gut bacteriome, virome, and serum metabolome in bipolar depression.Npj mental health research · 2026Article
- Sex-specific association between maternal integrative endocrine and metabolic status during pregnancy and preschoolers' emotional-behavioral development: A birth cohort study.European child & adolescent psychiatry · 2026Article
- Association between influenza A virus and SARS-CoV-2 infections and mood disorders.Brain, behavior, & immunity - health · 2026Article
- Emotion regulation habits and emotional states of college students during lockdown: A cross-sectional survey.World journal of psychiatry · 2026Article
- Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes.Molecular brain · 2026Article
- Exploring the relationship between family support and eating behaviors among college students with subjective well-being as the central mediating variable.Frontiers in psychology · 2026Article
- Lipid metabolism dysregulation in late-life depression: peripheral metabolic disturbance, central lipid alterations, and dietary modulation.Frontiers in nutrition · 2026Review
- Association between different dietary patterns and the risk of major brain disorders: a prospective multi-cohort study.EClinicalMedicine · 2025Article
- Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer's disease.Journal of advanced research · 2025Article
- Gut microbial tyramine facilitates intestinal damage and metabolic dysfunction-associated steatotic liver disease development.BMC medicine · 2025Article
- Acrylamide-Induced Neuroendocrine Disruption in Adult Male Zebrafish (Danio rerio): Mechanistic Insights into Locomotor, Neuronal, and Reproductive Impairments.Molecular neurobiology · 2025Article
- Permethrin induces epileptic susceptibility via activation of NaCommunications biology · 2025Article
- A new wide-scope, multi-biomarker wastewater-based epidemiology analytical method to monitor the health and well-being of inhabitants at a metropolitan scale.Analytical and bioanalytical chemistry · 2025Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Western dietary patterns have been unfavorably linked with mental health. However, the long-term effects of habitual fried food consumption on anxiety and depression and underlying mechanisms remain unclear. Our population-based study with 140,728 people revealed that frequent fried food consumption, especially fried potato consumption, is strongly associated with 12% and 7% higher risk of anxiety and depression, respectively. The associations were more pronounced among male and younger consumers. Consistently, long-term exposure to acrylamide, a representative food processing contaminant in fried products, exacerbates scototaxis and thigmotaxis, and further impairs exploration ability and sociality of adult zebrafish, showing anxiety- and depressive-like behaviors. Moreover, treatment with acrylamide significantly down-regulates the gene expression of
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