ArticleProceedings of the National Academy of Sciences of the United States of America2023
Allelic resolution of insect and spider silk genes reveals hidden genetic diversity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- A new phased assembly of the Antarctic spiny plunderfish provides novel insights into the evolution of the notothenioid radiation.Genome biology · 2026Article
- Article
- Morphological and compositional basis of silk fiber function inJournal of materials chemistry. B · 2026Article
- On the dynamic caddisfly silk H-fibroin gene: a population study in a net-spinning species.Molecular biology and evolution · 2026Article
- A new phased assembly of the Antarctic spiny plunderfish provides novel insights into the evolution of the notothenioid radiation.bioRxiv : the preprint server for biology · 2026Article
- Genomics of Caddisfly (Insecta: Trichoptera) Species Associated With Terrestrial Habitats.Ecology and evolution · 2026Article
- Article
- De Novo Whole Genome Assemblies of Unusual Case-Making Caddisflies (Trichoptera) Highlight Genomic Convergence in the Composition of the Major Silk Gene (h-fibroin).Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Dual roles of salivary proteins in feeding and silk fiber coating in the spider mite Tetranychus urticae.Communications biology · 2025Article
- Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology.Drug design, development and therapy · 2025Review
- Genomic resources of aquatic Lepidoptera, Elophila obliteralis and Hyposmocoma kahamanoa, reveal similarities with Trichoptera in amino acid composition of major silk genes.G3 (Bethesda, Md.) · 2024Article
- Evolution of Opsin Genes in Caddisflies (Insecta: Trichoptera).Genome biology and evolution · 2024Article
- De Novo Long-Read Genome Assembly and Annotation of the Luna Moth (Actias luna) Fully Resolves Repeat-Rich Silk Genes.Genome biology and evolution · 2024Article
- Phylogenomics recovers multiple origins of portable case making in caddisflies (Insecta: Trichoptera), nature's underwater architects.Proceedings. Biological sciences · 2024Article
- Overview and Evolution of Insect Fibroin Heavy Chain (FibH).International journal of molecular sciences · 2024Article
- Article
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Authors and funding
11 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthropod silk is vital to the evolutionary success of hundreds of thousands of species. The primary proteins in silks are often encoded by long, repetitive gene sequences. Until recently, sequencing and assembling these complex gene sequences has proven intractable given their repetitive structure. Here, using high-quality long-read sequencing, we show that there is extensive variation-both in terms of length and repeat motif order-between alleles of silk genes within individual arthropods. Further, this variation exists across two deep, independent origins of silk which diverged more than 500 Mya: the insect clade containing caddisflies and butterflies and spiders. This remarkable convergence in previously overlooked patterns of allelic variation across multiple origins of silk suggests common mechanisms for the generation and maintenance of structural protein-coding genes. Future genomic efforts to connect genotypes to phenotypes should account for such allelic variation.
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