ArticleProceedings of the National Academy of Sciences of the United States of America2023
Chemical factors induce aggregative multicellularity in a close unicellular relative of animals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- A smartphone analogy to explore the origin of animals.The EMBO journal · 2026Review
- Article
- The evolutionary foundations of transcriptional regulation in animals.Nature reviews. Genetics · 2025Review
- A close unicellular animal relative and predator of schistosomes exhibits chemokinesis in response to proteins and peptides from its prey.PLoS pathogens · 2025Article
- A red algal polysaccharide influences the multicellular development of the choanoflagellate Salpingoeca rosetta.Current biology : CB · 2025Article
- A close unicellular relative reveals aggregative multicellularity was key to the evolution of animals.bioRxiv : the preprint server for biology · 2025Article
- Chemokinesis by a microbial predator.bioRxiv : the preprint server for biology · 2025Article
- Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes.iScience · 2024Article
- Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.Trends in biochemical sciences · 2024Review
- Ichthyosporea: a window into the origin of animals.Communications biology · 2024Review
- Article
- Host lipids regulate multicellular behavior of a predator of a human pathogen.bioRxiv : the preprint server for biology · 2024Article
- The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Regulated cellular aggregation is an essential process for development and healing in many animal tissues. In some animals and a few distantly related unicellular species, cellular aggregation is regulated by diffusible chemical cues. However, it is unclear whether regulated cellular aggregation was part of the life cycles of the first multicellular animals and/or their unicellular ancestors. To fill this gap, we investigated the triggers of cellular aggregation in one of animals' closest unicellular living relatives-the filasterean
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.