Evidence map›Paper›PMID 37094121›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The origin of blinking in both mudskippers and tetrapods is linked to life on land.

Brett R Aiello, M Saad Bhamla, Jeff Gau, John G L Morris, Kenji Bomar, Shashwati da Cunha, Harrison Fu, Julia Laws, Hajime Minoguchi, Manognya Sripathi and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The Various Ways in Which Birds Blink.Animals : an open access journal from MDPI · 2023
    Article
  6. The origin of blinking in both mudskippers and tetrapods is linked to life on land.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Brett R AielloDepartment of Biology, Seton Hill University, Greensburg, PA 15601.ORCID 0000-0001-9034-0460
M Saad BhamlaSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-9788-9920
Jeff GauLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0003-1367-3848
John G L MorrisDepartment of Neurology, Westmead Hospital, Sydney, NSW 2145, Australia.
Kenji BomarLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Shashwati da CunhaSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Harrison FuLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Julia LawsLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Hajime MinoguchiLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-4040-489X
Manognya SripathiLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Kendra WashingtonLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Gabriella WongLiving Dynamical Systems Vertically Integrated Project Team, Georgia Institute of Technology, Atlanta, GA 30332.
Neil H ShubinDepartment Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637.
Simon SponbergSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0003-4942-4894
Thomas A StewartDepartment of Biology, The Pennsylvania State University, State College, PA 16802.
Georgia Institute of Technology · USPennsylvania State University · USUniversity of Chicago · USWestmead Hospital · AU

Funding

Biophysical mechanism and synthetic engineering of optically-controlled Ca2+-powered supramolecular enginesR35GM142588 · NIGMS · UNIVERSITY OF COLORADO · PI SAAD BHAMLA · 2021 to 2026
$4.4M
NIGMS NIH HHS R35 GM142588
6 · The paper itself

Abstract

Blinking, the transient occlusion of the eye by one or more membranes, serves several functions including wetting, protecting, and cleaning the eye. This behavior is seen in nearly all living tetrapods and absent in other extant sarcopterygian lineages suggesting that it might have arisen during the water-to-land transition. Unfortunately, our understanding of the origin of blinking has been limited by a lack of known anatomical correlates of the behavior in the fossil record and a paucity of comparative functional studies. To understand how and why blinking originates, we leverage mudskippers (Oxudercinae), a clade of amphibious fishes that have convergently evolved blinking. Using microcomputed tomography and histology, we analyzed two mudskipper species,

Indexed as

BlinkingPerciformesAnimalsFishesX-Ray Microtomographyevolutionary noveltyvisionwater-to-land transition

Identifiers

PMID37094121
PMCPMC10160996
OpenAlexW4366816411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.