Observational studyPLoS neglected tropical diseases2023
Effect of the time to antivenom administration on recovery from snakebite envenoming-related coagulopathy in French Guiana.
Observational study in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Use of snake antivenom in the Region of the Americas: a systematic review.Bulletin of the World Health Organization · 2025Pooled it
- Look what you make my tissues do: The role of metalloproteinases and their inhibitors in Bothrops snakebites.PLoS neglected tropical diseases · 2026Article
- Early vascular toxicity induced by Bothrops atrox venom in the chorioallantoic membrane assay: Kinetic profile and translational insights.PLoS neglected tropical diseases · 2026Article
- Effectiveness of late and very late antivenom administration on recovery from snakebite-induced coagulopathy in French Guiana: a population-based study.Lancet regional health. Americas · 2025Article
- A murine experimental model of the pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus.PLoS neglected tropical diseases · 2024Article
- Capacity of community health centers to treat snakebite envenoming in indigenous territories of the Brazilian Amazon.Toxicon : official journal of the International Society on Toxinology · 2024Article
- Development and validation of a minimum requirements checklist for snakebite envenoming treatment in the Brazilian Amazonia.PLoS neglected tropical diseases · 2024Article
- Bothrops venom-induced hemostasis disorders in the rat: Between Scylla and Charybdis.PLoS neglected tropical diseases · 2023Article
- Article
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSnakebite (SB) envenoming is an acute emergency requiring an early care delivery. We aimed to search for the time to reach healthcare facilities in various regions of French Guiana (FG) and to assess the impact of time to antivenom (AV) on the correction of coagulation parameters in these patients. METHODOLOGY: This is a prospective observational study conducted in Cayenne General Hospital between January 1st, 2016, and July 31st, 2022. We included all patients hospitalized for SB envenoming less than 48h after the bite, and receiving antivenom (AV). We assessed the time lapse between SB and medical attention and the time needed to return of the coagulation parameters to normal. PRINCIPAL
findingsOverall, 119 patients were investigated, and 48.7% were from remote areas. The median time from SB to AV therapy was 09:15 h (05:32-17:47). The time was longer in patients from remote rural locations. AV was dispensed within the first six hours after the SB in 45 cases (37.8%). Time from SB to reaching normal plasma fibrinogen concentration was 23:27 h (20:00-27:10) in patients receiving AV≤6h vs. 31:23 h (24:00-45:05) in those receiving AV>6h (p<0.001). Whereas, the time from AV administration to reach normal fibrinogen dosage was similar in the two groups.
conclusionsPatients from rural settings in FG suffer from a delay in AV administration after SB envenoming leading to an extended time in which patients are coagulopathic. Once AV is administered, clotting parameters recover at a similar rate. Supplying remote healthcare facilities with AV and with medical teams trained on its use should be planned.
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