Evidence map›Paper›PMID 37093786›Full record

ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2023

The Brain and Spinal Microvasculature in Normal Aging.

Zin Z Khaing, Abarajithan Chandrasekaran, Anjali Katta, May J Reed

Open access · greenAbstract readReview
In one paragraph

Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Charting Cervical Spinal Cord Morphometry Across the Lifespan.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zin Z KhaingDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-5652-5891
Abarajithan ChandrasekaranDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.
Anjali KattaDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.
May J ReedDepartment of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · US

Funding

Role of physical training and intraspinal hemodynamic changes in the recovery of forelimb function after cervical spinal cord injury in ratsR01NS121191 · NINDS · UNIVERSITY OF WASHINGTON · PI KHAING, ZIN Z · 2021 to 2025
$1.9M
Viable Microvessels for the Study of the Microvasculature in Alzheimer's DiseaseR21AG073676 · NIA · UNIVERSITY OF WASHINGTON · PI REED, MAY J · 2021 to 2022
$428k
The Microvasculature in Alzheimer’s Disease: Viable Microvessels for Studies of Brain Endothelial and Glycocalyx HealthR03AG075397 · NIA · UNIVERSITY OF WASHINGTON · PI REED, MAY J · 2022 to 2022
$156k
The Brain Microvasculature, Hyaluronan, and AgingR03AG051071 · NIA · UNIVERSITY OF WASHINGTON · PI REED, MAY J · 2015 to 2016
$155k
NIA NIH HHS R03 AG051071NIA NIH HHS R03 AG075397NIA NIH HHS R21 AG073676NINDS NIH HHS R01 NS121191
6 · The paper itself

Abstract

Changes in the brain and spinal cord microvasculature during normal aging contribute to the "sensitive" nature of aged central nervous system tissue to ischemic insults. In this review, we will examine alterations in the central nervous system microvasculature during normal aging, which we define as aging without a dominant pathology such as neurodegenerative processes, vascular injury or disease, or trauma. We will also discuss newer technologies to improve the study of central nervous system microvascular structure and function. Microvasculature within the brain and spinal cord will be discussed separately as anatomy and physiology differ between these compartments. Lastly, we will identify critical areas for future studies as well as key unanswered questions.

Indexed as

BrainSpinal CordMicrovesselsBrainMicrovesselsNormal agingSpinal cord

Identifiers

PMID37093786
PMCPMC10395569
OpenAlexW4366819785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.