Evidence map›Paper›PMID 37093780›Full record

ArticleChemical research in toxicology2023

8-Oxo-2'-deoxyguanosine Replication in Mutational Hot Spot Sequences of the

Stephen Stanio, Jan Henric T Bacurio, Haozhe Yang, Marc M Greenberg, Ashis K Basu

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephen StanioDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Jan Henric T BacurioDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Haozhe YangDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Marc M GreenbergDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0002-5786-6118
Ashis K BasuDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0001-7951-4984
University of Connecticut · USJohns Hopkins University · US

Funding

How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and ApplicationsR35GM131736 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MARC M GREENBERG · 2019 to 2026
$4.3M
Biochemical studies on Fapy-dG with eukaryotic enzymes and in mammalian cellsR01ES027558 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GREENBERG, MARC M · 2017 to 2021
$1.7M
NIEHS NIH HHS R01 ES027558NIGMS NIH HHS R35 GM131736
6 · The paper itself

Abstract

7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-OxodGuo) is a ubiquitous DNA damage formed by oxidation of 2'-deoxyguanosine. In this study, plasmid DNA containing 8-OxodGuo located in three mutational hot spots of human cancers, codons 248, 249, and 273 of the

Indexed as

Genes, p53Mutagens8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineDNA DamageDNA ReplicationFormamidesFuransHumansMutagenesisMutationPyrimidines8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineFormamidesFuransMutagensN6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidinePyrimidines

Identifiers

PMID37093780
PMCPMC10192040
OpenAlexW4366819302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.