Evidence map›Paper›PMID 37093746›Full record

ArticleMagnetic resonance in medicine2023

Severity of polycystic kidney disease revealed by multiparametric MRI.

Feng Wang, Seo Yeon Lee, Fatemeh Adelnia, Keiko Takahashi, Kevin D Harkins, Lilly He, Zhongliang Zu, Philipp Ellinger, Manuel Grundmann, Raymond C Harris and 2 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Feng WangVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-8965-7708
Seo Yeon LeeDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Fatemeh AdelniaVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Keiko TakahashiVanderbilt O'Brien Kidney Research Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kevin D HarkinsVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lilly HeDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zhongliang ZuVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-7361-7480
Philipp EllingerPharmaceuticals, Bayer AG Research & Development, Wuppertal, Germany.
Manuel GrundmannPharmaceuticals, Bayer AG Research & Development, Wuppertal, Germany.
Raymond C HarrisVanderbilt O'Brien Kidney Research Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Takamune TakahashiVanderbilt O'Brien Kidney Research Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University Medical Center · USBayer (Germany) · DEVanderbilt University · US

Funding

The Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1M
The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4M
The Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, MATTHEW H · 2017 to 2021
$5.9M
Vanderbilt O'Brien Mouse Kidney Physiology and Disease CenterP30DK079341 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2008 to 2013
$4.4M
Proton Relaxation and Exchange Contrast in MRIR01EB024525 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZU, ZHONGLIANG · 2018 to 2021
$2.0M
Development and Application of T1rho Dispersion Imaging of Aging MuscleK25AG076864 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Fatemeh Adelnia · 2022 to 2026
$629k
Upgrade of a 7T Small Animal MRI/MRS SystemS10OD019993 · OD · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2015 to 2015
$600k
BLRD VA I01 BX000320NIA NIH HHS K25 AG076864NIBIB NIH HHS R01 EB024525NIDDK NIH HHS P30 DK079341NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK095785NIH HHS S10 OD019993
6 · The paper itself

Abstract

purposeWe aimed to compare multiple MRI parameters, including relaxation rates (

methodsPcy/Pcy mice with CD1 strain, a mouse model of autosomal dominant PKD, were imaged at 5, 9, and 26 wk of age using a 7T MRI system. Twelve-week normal CD1 mice were used as controls. Post-mortem paraffin tissue sections were stained using hematoxylin and eosin and picrosirius red to identify histological changes.

resultsHistology detected segmental cyst formation in the early stage (week 5) and progression of PKD over time in Pcy kidneys. In

conclusion

Indexed as

CystsMultiparametric Magnetic Resonance ImagingPolycystic Kidney DiseasesAnimalsDisease Models, AnimalKidneyMagnetic Resonance ImagingMicediffusion weighted imagingmagnetization transferMRIpolycystic kidney disease (PKD)relaxationspin-lock

Identifiers

PMID37093746
PMCPMC10805116
OpenAlexW4366814572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.