Evidence map›Paper›PMID 37093441›Full record

ArticleInternational urology and nephrology2023

Associated factors of osteoporosis and vascular calcification in patients awaiting kidney transplantation.

Junhao Lv, Wenqin Xie, Suya Wang, Yilin Zhu, Yaomin Wang, Ping Zhang, Jianghua Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Junhao Lv *Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Wenqin Xie *Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Suya WangKidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yilin ZhuKidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yaomin WangKidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Ping ZhangKidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Jianghua ChenKidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China. zjukidney@zju.edu.cn.ORCID http://orcid.org/0000-0001-6061-5697
Hangzhou Center for Disease Control and Prevention · CN

Funding

Chinese Society of Nephrology Grant No.18020040783Clinical Research Foundation of Zhejiang Medical Association 2018ZYC-A12
6 · The paper itself

Abstract

introductionPretransplant osteoporosis and vascular calcification probably increase the risk of fractures and cardiovascular events after kidney transplantation. In the present study, we investigated the related risk factors of osteoporosis and vascular calcification among end-stage renal disease (ESRD) patients awaiting kidney transplantation.

methodsA total of 221 ESRD patients (age, 43.4 ± 14.3 years; 125 males and 96 females; median dialysis duration, 61.0 m) awaiting kidney transplantation were enrolled in this cross-sectional study. Serum levels of bone turnover markers and intact parathyroid hormone (iPTH) were analyzed from fasting morning blood samples. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD). Vascular calcification was evaluated by lateral abdominal radiography and plain radiographic films of the pelvis and hands.

resultsThe osteoporosis prevalence was 27.6% in this cohort of kidney transplantation candidates, and the prevalence of vascular calcification was 51.1%. The related factors for osteoporosis and vascular calcification were similar and included older age, longer dialysis duration, parathyroid hyperplasia, and higher levels of iPTH and bone turnover markers. In the multivariable regression model, age and iPTH were independent risk predictors of both vascular calcification and osteoporosis. There were strong, positive correlations between iPTH and all bone turnover markers. The moderate and severe hyperparathyroidism (iPTH 600-1499 pg/ml and iPTH 1500 pg/ml) were related to reduced serum albumin and hemoglobin levels.

conclusionThe involvement of high iPTH levels in vascular calcification, osteoporosis, and malnutrition indicated the need of treating hyperparathyroidism early in patients awaiting kidney transplantation. Prospective studies are needed to further examine the utility of bone turnover markers.

Indexed as

HyperparathyroidismKidney Failure, ChronicKidney TransplantationOsteoporosisVascular CalcificationAdultBone DensityCross-Sectional StudiesFemaleHumansMaleMiddle AgedParathyroid HormoneParathyroid HormoneBone turnover markersOsteoporosisSecondary hyperparathyroidismVascular calcification

Identifiers

PMID37093441
PMCPMC10611617
OpenAlexW4366822545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.