Evidence map›Paper›PMID 37093341›Full record

ArticleMolecular diversity2024

Design, synthesis and biological activity evaluation of novel covalent S-acylation inhibitors.

Wei Yu, Kan Yang, Mengmiao Zhao, Han Liu, Zhihao You, Zhenming Liu, Xiaoqiang Qiao, Yali Song

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei YuKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China.
Kan YangKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China.
Mengmiao ZhaoKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China.
Han LiuKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China.
Zhihao YouKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China.
Zhenming LiuState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Xiaoqiang QiaoKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China. xiaoqiao@hbu.edu.cn.
Yali SongKey Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China. yalisong@hbu.edu.cn.ORCID http://orcid.org/0000-0002-7011-6741

Funding

Hebei youth talent project; the Innovation Capacity Improvement Plan of Hebei Province 20567605HNational Natural Science Foundation of China 82003597National Natural Science Foundation of China 82273792Natural Science Foundation of Hebei Province B2021201026Natural Science Foundation of Hebei Province B2022201092Natural Science Interdisciplinary Research Program of Hebei University DXK201912Post-graduate's Innovation Found Project of Hebei University HBU2022ss036Science and Technology Project of Hebei Education Department QN2021023
6 · The paper itself

Abstract

In order to obtain diverse S-acylation inhibitors and address the defects of existing S-acylation inhibitors, a series of novel covalent S-acylation inhibitors are designed through synthesis. According to the results of MTT assay, most compounds produce a better anti-proliferation effect on MCF-7, MGC-803 and U937 cell lines than 2-BP. Among them, 8d, 8i, 8j and 10e exert a significant inhibitory effect on MCF-7 cell, with the IC

Indexed as

Antineoplastic AgentsApoptosisCell ProliferationDrug DesignMolecular Docking SimulationAcylationAnimalsCell Line, TumorCell MovementHumansMCF-7 CellsMiceStructure-Activity RelationshipAntineoplastic AgentsAntitumorCovalent inhibitorsDHHCS-acylation

Identifiers

PMID37093341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.