Evidence map›Paper›PMID 37093319›Full record

ReviewWorld journal of urology2023

Impact of smoking on urologic cancers: a snapshot of current evidence.

Raj Kumar, Richard Matulewicz, Andrea Mari, Marco Moschini, Saum Ghodoussipour, Benjamin Pradere, Michael Rink, Riccardo Autorino, Mihir M Desai, Inderbir Gill and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Urolithiasis in patients with cancer.Nature reviews. Urology · 2026
    Review
  5. Observational
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  19. Diabetes and Prostate Cancer Outcomes in Men with Nonmetastatic Castration-Resistant Prostate Cancer: Results from the SEARCH Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Raj KumarThe Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Richard MatulewiczDepartment of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Andrea MariDepartment of Urology, Careggi Hospital, University of Florence, Florence, Italy.
Marco MoschiniDepartment of Urology, La Croix du Sud Hospital, 31130, Quint Fonsegrives, France.
Saum GhodoussipourBladder and Urothelial Cancer Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Benjamin PradereDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Michael RinkDepartment of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Riccardo AutorinoDivision of Urology, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA.
Mihir M DesaiThe Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Inderbir GillThe Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Giovanni E CacciamaniThe Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA. giovanni.cacciamani@med.usc.edu.ORCID http://orcid.org/0000-0002-8892-5539
University of Southern California · USComprehensive Cancer Center Vienna · ATLyon Genou Centre Albert Trillat · FRMemorial Sloan Kettering Cancer Center · USRutgers, The State University of New Jersey · USUniversität Hamburg · DEUniversity of Florence · ITVirginia Commonwealth University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Optimizing Smoking Cessation Treatment for Patients with Bladder CancerK08CA259452 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Richard Steven Matulewicz · 2022 to 2026
$971k
NCI NIH HHS K08 CA259452NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeThe purpose of this paper is to present evidence regarding the associations between smoking and the following urologic cancers: prostate, bladder, renal, and upper tract urothelial cancer (UTUC).

methodsThis is a narrative review. PubMed was queried for evidence-based analyses and trials regarding the associations between smoking and prostate, bladder, renal, and UTUC tumors from inception to September 1, 2022. Emphasis was placed on articles referenced in national guidelines and protocols.

resultsProstate-multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion. Though smoking has not yet been linked to tumorigenesis, there is evidence that it plays a role in biochemical recurrence and cancer-specific mortality. Bladder-smoking is strongly associated with bladder cancer, likely due to DNA damage from the release of carcinogenic compounds. Additionally, smoking has been linked to increased cancer-specific mortality and higher risk of tumor recurrence. Renal-smoking tobacco has been associated with tumorigenesis, higher tumor grade and stage, poorer mortality rates, and a greater risk of tumor recurrence. UTUC-tumorigenesis has been associated with smoking tobacco. Additionally, more advanced disease, higher stage, lymph node metastases, poorer survival outcomes, and tumor recurrence have been linked to smoking.

conclusionSmoking has been shown to significantly affect most urologic cancers and has been associated with more aggressive disease, poorer outcomes, and tumor recurrence. The role of smoking cessation is still unclear, but appears to provide some protective effect. Urologists have an opportunity to engage in primary prevention by encouraging cessation practices.

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsUrologic NeoplasmsCarcinogenesisHumansMaleNeoplasm Recurrence, LocalPrognosisRetrospective StudiesSmokingSmokingSmoking cessationTumor recurrenceUrologic oncology

Identifiers

PMID37093319
PMCPMC10241723
OpenAlexW4366819476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.