Evidence map›Paper›PMID 37093222›Full record

ArticleBiomacromolecules2023

Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery.

Maximilian Scherger, Yannick A Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Kaloian Koynov, Hans Joachim Räder, Lutz Nuhn

Abstract read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maximilian SchergerMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Yannick A PilgerChair of Macromolecular Chemistry, Julius-Maximilians-University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Judith StickdornMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Patric KomforthMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Sascha SchmittMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Kaloian KoynovMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0002-4062-8834
Hans Joachim RäderMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0002-7292-4013
Lutz NuhnMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0003-0761-1106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reversible addition-fragmentation chain-transfer (RAFT) polymerization provides access to a broad variety of biocompatible and functional macromolecules for diverse polymer-drug conjugates. Due to thiocarbonylthio groups at the ends of each growing polymer chain, they can straightforwardly be converted into disufilde-containing self-immolative motives for reversible drug conjugation by traceless linkers. This may be relevant for RAFT-polymerized poly(

Indexed as

Polyethylene GlycolsPolymersChemical PhenomenaPolymerizationPolyethylene GlycolsPolymers

Identifiers

PMID37093222
PMCPMC10170519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.