Evidence map›Paper›PMID 37093065›Full record

ArticlemSphere2023

Adaptation of Prokaryotic Toxins for Negative Selection and Cloning-Independent Markerless Mutagenesis in Streptococcus Species.

Lena Li, Madeline Krieger, Hua Qin, Zhengzhong Zou, Jens Kreth, Justin Merritt

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lena LiDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Madeline KriegerDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Hua QinDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Zhengzhong ZouDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Jens KrethDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-8599-8310
Justin MerrittDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-3464-0490
Oregon Health & Science University · US

Funding

Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
$424k
NIDCR NIH HHS R01 DE029492NIDCR NIH HHS R21 DE029612NIDCR NIH HHS R35 DE028252
6 · The paper itself

Abstract

The Streptococcus mutans genetic system offers a variety of strategies to rapidly engineer targeted chromosomal mutations. Previously, we reported the first S. mutans negative selection system that functions in a wild-type background. This system utilizes induced sensitivity to the toxic amino acid analog

Indexed as

StreptococcusXyloseCloning, MolecularMutagenesisMutationXylosecounterselectionmarkerless mutationnegative selectionStreptococcustoxin-antitoxinxylose

Identifiers

PMID37093065
PMCPMC10286703
OpenAlexW4366822179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.