Evidence map›Paper›PMID 37093060›Full record

ArticleMicrobiology spectrum2023

SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital.

Kara K Tsang, Shehryar Ahmad, Alanoud Aljarbou, Mohammed Al Salem, Sheridan J C Baker, Emily M Panousis, Hooman Derakhshani, Laura Rossi, Jalees A Nasir, David C Bulir and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Kara K Tsang *Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0001-7742-8855
Shehryar Ahmad *Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-2747-5212
Alanoud AljarbouDepartment of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Mohammed Al SalemDepartment of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Sheridan J C BakerMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Emily M PanousisMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Hooman DerakhshaniDepartment of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Laura RossiFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jalees A NasirMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-6582-9085
David C BulirDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Michael G SuretteFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-0086-4995
Robyn S LeeEpidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Fiona SmaillMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Dominik MertzMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-4337-1613
Andrew G McArthurMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-1142-3063
Sarah KhanDepartment of Pediatrics, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-8498-2643
McMaster University · CAPopulation Health Research Institute · CAUniversity of Toronto · CAImam Mohammad ibn Saud Islamic University · SALondon School of Hygiene & Tropical Medicine · GBUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic epidemiology can facilitate an understanding of evolutionary history and transmission dynamics of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. We used next-generation sequencing techniques to study SARS-CoV-2 genomes isolated from patients and health care workers (HCWs) across five wards of a Canadian hospital with an ongoing SARS-CoV-2 outbreak. Using traditional contact tracing methods, we show transmission events between patients and HCWs, which were also supported by the SARS-CoV-2 lineage assignments. The outbreak predominantly involved SARS-CoV-2 B.1.564.1 across all five wards, but we also show evidence of community introductions of lineages B.1, B.1.1.32, and B.1.231, falsely assumed to be outbreak related. Altogether, our study exemplifies the value of using contact tracing in combination with genomic epidemiology to understand the transmission dynamics and genetic underpinnings of a SARS-CoV-2 outbreak.

Indexed as

COVID-19SARS-CoV-2Contact TracingDisease OutbreaksHumansOntarioTertiary Care CentersCanadacontact tracingCOVID-19DNA sequencinggenomicshospitaloutbreakSARS-CoV-2

Identifiers

PMID37093060
PMCPMC10269621
OpenAlexW4366819684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.