ArticlePathophysiology : the official journal of the International Society for Pathophysiology2023
Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study.
Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Investigating the Relationship Between Estrogen Replacement Therapy and Postoperative Complications Following Single-Level Lumbar Fusion: A Propensity Matched Analysis.Global spine journal · 2026Article
- Testosterone Replacement Therapy is Associated With Increased Risk of Pseudarthrosis After Single-Level Anterior Cervical Discectomy and Fusion: A Propensity Matched Analysis.Global spine journal · 2026Article
- Effect of Preoperative Hormone Replacement Therapy on Postmenopausal Women Undergoing Rotator Cuff Repair.Cureus · 2026Article
- Article
- Risk of complications after total hip arthroplasty in patients on testosterone replacement therapy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Advanced Biomaterial-Based In Vitro Osteoarthritis Models: Integrating Sex as a Biological Variable in Hormonal, Subchondral Bone, and Mechanobiological Pathways.Journal of functional biomaterials · 2026Review
- Preoperative testosterone replacement therapy: a potential risk-factor for complications and reoperation after rotator cuff repair.JSES international · 2026Article
- Association of Testosterone Supplementation with the Risk of Infection following Primary Total Hip Arthroplasty.Hip & pelvis · 2025Article
- Impact of estrogen replacement therapy on outcomes following total shoulder arthroplasty: a propensity-matched retrospective cohort study of 1,779 patients.JSES international · 2025Article
- Geographical incidence of testosterone supplementation in total hip and knee arthroplasty.Journal of orthopaedics · 2025Article
- Testosterone Replacement Therapy Is Not Associated with Greater Revision Rates in Reverse Total Shoulder Arthroplasty.Journal of clinical medicine · 2025Article
- The effects of pre-operative anti-osteoporotic use on total joint arthroplasty complications: A national database study.Journal of orthopaedics · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years following a THA and increased rates of septic and aseptic revisions, and aseptic loosening after TKA compared to the control cohort. Patients receiving ERT had increased rates of aseptic loosening and pooled joint complications within 2 years following THA and increased rates of all-cause revisions and pooled joint complications after TKA. Patients who received TRT demonstrated significantly higher rates of revision rates and PJI. Patients who received perioperative ERT were significantly more likely to have increased risks of revision rates and joint infections.
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Registered trials
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