Evidence map›Paper›PMID 37092449›Full record

ArticleAntibodies (Basel, Switzerland)2023

Establishment and Functional Characterization of Murine Monoclonal Antibodies Recognizing Neuritin.

Georgia Papadogianni, Inga Ravens, Ahmed Hassan, Andrew Flatley, Regina Feederle, Günter Bernhardt, Hristo Georgiev

Open access · goldAbstract read
In one paragraph

Article in Antibodies (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Georgia PapadogianniInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Inga RavensInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Ahmed HassanInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Andrew FlatleyMonoclonal Antibody Core Facility, Helmholtz Center Munich, Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.ORCID 0000-0001-7822-132X
Regina FeederleMonoclonal Antibody Core Facility, Helmholtz Center Munich, Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.ORCID 0000-0002-3981-367X
Günter BernhardtInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Hristo GeorgievInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-1369-960X
Medizinische Hochschule Hannover · DEHelmholtz Zentrum München · DE

Funding

Deutsche Forschungsgemeinschaft GE3062/2-1
6 · The paper itself

Abstract

Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells. We established monoclonal mouse anti-mouse neuritin antibodies by immunizing knock-out mice with two different neuritin-derived peptides. Because neuritin is well conserved between species, these new monoclonal antibodies recognize the neuritin of a wide variety of species, including human. Moreover, they not only recognize specifically surface-bound neuritin expressed by murine follicular regulatory T cells but also the block binding of recombinant neuritin to germinal center B cells. This suggests that these newly generated tools will be of great use in studying neuritin expression and function.

Indexed as

blocking antibodyELISAflow cytometrymonoclonal antibodyneuritin

Identifiers

PMID37092449
PMCPMC10123642
OpenAlexW4362733383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.