Evidence map›Paper›PMID 37092262›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors.

Simone Giovannuzzi, Alessandro Bonardi, Paola Gratteri, Alessio Nocentini, Claudiu T Supuran

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Drug Design of Carbonic Anhydrase Inhibitors.Sub-cellular biochemistry · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Simone GiovannuzziNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze, Italy.
Alessandro BonardiNEUROFARBA Department, Laboratory of Molecular Modeling, Cheminformatics & QSAR, University of Florence, Firenze, Italy.
Paola GratteriNEUROFARBA Department, Laboratory of Molecular Modeling, Cheminformatics & QSAR, University of Florence, Firenze, Italy.ORCID 0000-0002-9137-2509
Alessio NocentiniNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze, Italy.ORCID 0000-0003-3342-702X
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze, Italy.ORCID 0000-0003-4262-0323
Laboratory of Molecular Genetics · PLUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was planned considering a unique feature of its active site among the other hCA isoforms,

Indexed as

Carbonic Anhydrase InhibitorsDrug DesignSulfonamidesHumansMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureCarbonic Anhydrase InhibitorsSulfonamidesclick chemistryDrug designhCA IIIinhibitionmetalloenzymemolecular dynamics

Identifiers

PMID37092262
PMCPMC10128460
OpenAlexW4366819517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.