Evidence map›Paper›PMID 37092221›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Associations Between Midlife Menopausal Hormone Therapy Use, Incident Diabetes, and Late Life Memory in the Wisconsin Longitudinal Study.

Victoria J Williams, Rebecca Koscik, Kamil Sicinski, Sterling C Johnson, Pamela Herd, Sanjay Asthana

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Victoria J WilliamsDepartment of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI, USA.
Rebecca KoscikDepartment of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI, USA.
Kamil SicinskiCenter for Demography of Health and Aging, University of Wisconsin at Madison, Madison, WI, USA.
Sterling C JohnsonDepartment of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI, USA.
Pamela HerdMcCourt School of Public Policy, Georgetown University, Washington, DC, USA.
Sanjay AsthanaDepartment of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI, USA.

Funding

Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)R01AG060737 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana, Michal Engelman · 2018 to 2026
$56.8M
WISCONSIN LONGITUDINAL STUDY--SIBLING INTERVIEWS (1)R01AG009775 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HERD, PAMELA · 1991 to 2012
$23.4M
NIA NIH HHS R01 AG009775NIA NIH HHS R01 AG060737
6 · The paper itself

Abstract

backgroundPrior research suggests a link between menopausal hormone therapy (MHT) use, memory function, and diabetes risk. The menopausal transition is a modifiable period to enhance long-term health and cognitive outcomes, although studies have been limited by short follow-up periods precluding a solid understanding of the lasting effects of MHT use on cognition.

objectiveWe examined the effects of midlife MHT use on subsequent diabetes incidence and late life memory performance in a large, same-aged, population-based cohort. We hypothesized that the beneficial effects of MHT use on late life cognition would be partially mediated by reduced diabetes risk.

methods1,792 women from the Wisconsin Longitudinal Study (WLS) were included in analysis. We employed hierarchical linear regression, Cox regression, and causal mediation models to test the associations between MHT history, diabetes incidence, and late life cognitive performance.

results1,088/1,792 women (60.7%) reported a history of midlife MHT use and 220/1,792 (12.3%) reported a history of diabetes. MHT use history was associated with better late life immediate recall (but not delayed recall), as well as a reduced risk of diabetes with protracted time to onset. Causal mediation models suggest that the beneficial effect of midlife MHT use on late life immediate recall were at least partially mediated by diabetes risk.

conclusionOur data support a beneficial effect of MHT use on late life immediate recall (learning) that was partially mediated by protection against diabetes risk, supporting MHT use in midlife as protective against late life cognitive decline and adverse health outcomes.

Indexed as

Diabetes MellitusMenopauseCognitionFemaleHumansLongitudinal StudiesWisconsinAdult onset diabetes mellitusAlzheimer’s diseaseestrogenimmediate memorymediationmenopause

Identifiers

PMID37092221
PMCPMC10551825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.