Evidence map›Paper›PMID 37092138›Full record

ArticleCurrent pathobiology reports2019

Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology.

David A Mankoff, Austin R Pantel, Varsha Viswanath, Joel S Karp

Open access · greenAbstract read
In one paragraph

Article in Current pathobiology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Expert consensus on workflow of PET/CT with long axial field-of-view.European journal of nuclear medicine and molecular imaging · 2025
    Review
  4. Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023
    Review
  5. Article
  6. Total-body PET: a new paradigm for molecular imaging.The British journal of radiology · 2022
    Review
  7. Principles of Tracer Kinetic Analysis in Oncology, Part II: Examples and Future Directions.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Total Body PET: Why, How, What for?IEEE transactions on radiation and plasma medical sciences · 2020
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David A MankoffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Austin R PantelDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Varsha ViswanathDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Joel S KarpDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Hospital of the University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PETR01CA206187 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADAWI, RAMSEY D., CHERRY, SIMON R · 2015 to 2019
$15.5M
Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
Time-of-Flight PET for Improved Whole-Body ImagingR01CA113941 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JOEL S KARP, Suleman Surti · 2006 to 2026
$9.8M
PennPET Explorer Scanner With Scalable Axial Length for Total Body PET ImagingR01CA225874 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KARP, JOEL S · 2019 to 2023
$3.0M
Molecular Imaging Markers for Glutaminolysis in Breast CancerR01CA211337 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MANKOFF, DAVID A., ZHOU, RONG · 2017 to 2021
$2.0M
Area B: Multi-Tracer Volumetric PET (MTV-PET) to Measure Tumor Glutamine and Glucose Metabolic Rates in a Single Imaging SessionR33CA225310 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KARP, JOEL S, MANKOFF, DAVID A. · 2017 to 2017
$1.4M
NCATS NIH HHS KL2 TR001879NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA113941NCI NIH HHS R01 CA206187NCI NIH HHS R01 CA211337NCI NIH HHS R01 CA225874NCI NIH HHS R33 CA225310
6 · The paper itself

Abstract

Purpose of the Review: We present an overview of recent advances in positron emission tomography (PET) diagnostics as applied to the study of cancer, specifically as a tool to study in vivo cancer biology and to direct targeted cancer therapy. The review is directed to translational and clinical cancer investigators who may not be familiar with these applications of PET cancer diagnostics, but whose research might benefit from these advancing tools. Recent Findings: We highlight recent advances in 3 areas: (1) the translation of PET imaging cancer biomarkers to clinical trials; (2) methods for measuring cancer metabolism in vivo in patients; and (3) advances in PET instrumentation, including total-body PET, that enable new methodologies. We emphasize approaches that have been translated to human studies. Summary: PET imaging methodology enables unique in vivo cancer diagnostics that go beyond cancer detection and staging, providing an improved ability to guide cancer treatment and an increased understanding of in vivo human cancer biology.

Indexed as

cancer imaging biomarkerscancer metabolismPET instrumentationposition emission tomography (PET)total-body PET

Identifiers

PMID37092138
PMCPMC10117535
OpenAlexW2963089716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.