Evidence map›Paper›PMID 37091921›Full record

ArticleFrontiers in cellular neuroscience2023

SARM1 detection in myelinating glia:

Shaline V Fazal, Clara Mutschler, Civia Z Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Zebrafish (International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Shaline V FazalDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
Clara MutschlerDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
Civia Z ChenWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Mark TurmaineDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Chiung-Ya ChenInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Yi-Ping HsuehInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Andrea Ibañez-GrauInstituto de Neurociencias de Alicante, Universidad Miguel Hernández, Alicante, Spain.
Andrea LoretoDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
Angeles Casillas-BajoInstituto de Neurociencias de Alicante, Universidad Miguel Hernández, Alicante, Spain.
Hugo CabedoInstituto de Neurociencias de Alicante, Universidad Miguel Hernández, Alicante, Spain.
Robin J M FranklinWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Roger A BarkerDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
Kelly R MonkVollum Institute, Oregon Health & Science University, Portland, OR, United States.
Benjamin J SteventonDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Michael P ColemanDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
Jose A Gomez-SanchezInstituto de Neurociencias de Alicante, Universidad Miguel Hernández, Alicante, Spain.
Peter Arthur-FarrajDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GBInstitute of Molecular Biology, Academia Sinica · TWInstituto de investigación sanitaria y biomédica de AlicanteInstituto de Neurociencias · ESOregon Health & Science University · USUniversity College London · GBWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.R01NS079445 · NINDS · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2012 to 2020
$3.1M
Medical Research Council MC_PC_17230NINDS NIH HHS R01 NS079445Wellcome Trust 206634/Z/17/ZWellcome Trust 210904/Z/18/Z
6 · The paper itself

Abstract

Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1 has been extensively studied in neurons, it remains unknown whether SARM1 is present and functional in myelinating glia? This is an important question to address. Firstly, to identify whether SARM1 dysfunction in other cell types in the nervous system may contribute to neuropathology in SARM1 dependent diseases? Secondly, to ascertain whether therapies altering SARM1 function may have unintended deleterious impacts on PNS or CNS myelination? Surprisingly, we find that oligodendrocytes express

Indexed as

mousemyelinationoligodendrocyteSARM1Schwann cellzebrafish

Identifiers

PMID37091921
PMCPMC10113485
OpenAlexW4362626361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.