ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2023
Association between Interactions among ACE Gene Polymorphisms and Essential Hypertension in Patients in the Hefei Region, Anhui, China.
Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Antihypertensive drugs for hyperuricemia in patients with hypertension: a systematic review and network meta-analysis of Chinese trials.BMC cardiovascular disorders · 2025Pooled it
- Impact of pulse pressure variability evaluated by visit-to-visit on heart failure events in patients with hypertension: insights from the SPRINT trial.European journal of medical research · 2024Trial
- Multiomics: the intersection of personalized nutrition in cardiometabolic diseases.Journal of translational medicine · 2026Review
- Construction of a nomogram prediction model for obstructive sleep apnea combined with hypertension via polysomnography: a single-center retrospective study.European journal of medical research · 2025Article
- Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among patients with hypertension in the US.BMC cardiovascular disorders · 2025Article
- Impact of epicardial adipose tissue volume and hypertension on left ventricular hypertrophy in preclinical heart failure patients with metabolic syndrome.BMC cardiovascular disorders · 2025Article
- Lactate-to-albumin ratio and 28 day mortality in hypertensive patients with atrial fibrillation: a retrospective cohort study.European journal of medical research · 2025Article
- Red cell distribution width-to-albumin ratio and hypertension risk: age-specific threshold effects identified in the 2017-2020 NHANES U.S. Adult population.BMC cardiovascular disorders · 2025Article
- Association between novel Immune-Inflammatory markers and hypertension patients with coronary heart disease: A Cross-Sectional study based on NHANES (2005-2016).BMC cardiovascular disorders · 2025Article
- Article
- Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Review
- ACE gene polymorphism and susceptibility to hypertension in a Jordanian adult population.PloS one · 2024Article
- Genetic diet interactions ofFrontiers in nutrition · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Essential hypertension (EH) is a common cardiovascular disease that endangers human health. Its pathogenesis is complex and has not been fully elucidated. We explore the association between EH and interactions among polymorphisms of the angiotensin converting enzyme (ACE) gene in the Hefei region, Anhui, China. Methods: A total of 500 participants (400 hypertensive and 100 normotensive) were included in this study. The polymorphisms were detected via improved multiple ligase detection reaction (iMLDR). To improve the accuracy of prediction, multifactor dimensionality reduction (MDR) was used to analyze the overall effect of interactions among seven loci on the incidence of EH. Results: The frequencies of polymorphisms in the ACE genes rs12709426, rs4291, rs4309, rs4331, rs4343, rs4459609, and rs4461142 in the EH group were not statistically significantly different from those in the control group. We also found that the single nucleotide polymorphism (SNP) rs12709426 only had a homozygous AA genotype and no polymorphisms. There were no differences in the frequency of genetic polymorphisms between the EH and control groups. The best model explaining the EH group was the combined effect of ACE genes rs4291, rs4309, and rs4461142. Conclusion: There is an interaction effect among ACE gene loci in EH patients in Hefei region, Anhui, China. Also, the ACE gene SNP rs12709426 only has a homozygous AA genotype and does not show an association with EH.
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