Evidence map›Paper›PMID 37091522›Full record

ArticleFrontiers in aging neuroscience2023

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis.

Ipinuoluwakiye Fatokun, Myrlene Gee, Krista Nelles, Fang Ba, Mahsa Dadar, Simon Duchesne, Breni Sharma, Mario Masellis, Sandra E Black, Quincy J Almeida and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Ipinuoluwakiye FatokunDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Myrlene GeeDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Krista NellesDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Fang BaDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Mahsa DadarDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada.
Simon DuchesneDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Laval University, Québec City, QC, Canada.
Breni SharmaCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Mario MasellisDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Sandra E BlackDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Quincy J AlmeidaMovement Disorders Research and Rehabilitation Consortium, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, Canada.
Eric E SmithCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Frederico Pieruccini-FariaGait and Brain Lab, Parkwood Institute Research and Lawson Health Research Institute, London, ON, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institute Research and Lawson Health Research Institute, London, ON, Canada.
Richard CamicioliDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CASunnybrook Health Science Centre · CAUniversity of Calgary · CAWestern University · CADouglas Mental Health University Institute · CAUniversité Laval · CAWilfrid Laurier University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are part of a spectrum of Lewy body disorders, who exhibit a range of cognitive and gait impairments. Cognitive-motor interactions can be examined by performing a cognitive task while walking and quantified by a dual task cost (DTC). White matter hyperintensities (WMH) on magnetic resonance imaging have also been associated with both gait and cognition. Our goal was to examine the relationship between DTC and WMH in the Lewy body spectrum, hypothesizing DTC would be associated with increased WMH volume. Methods: Seventy-eight participants with PD, PD with mild cognitive impairment (PD-MCI), PD with dementia or DLB (PDD/DLB), and 20 cognitively unimpaired participants were examined in a multi-site study. Gait was measured on an electronic walkway during usual gait, counting backward, animal fluency, and subtracting sevens. WMH were quantified from magnetic resonance imaging using an automated pipeline and visual rating. A median split based on DTC was performed. Models included age as well as measures of global cognition and cardiovascular risk. Results: Compared to cognitively unimpaired participants, usual gait speed was lower and DTC was higher in PD-MCI and PDD/DLB. Low DTC participants had higher usual gait speed. WMH burden was greater in high counting DTC participants. Frontal WMH burden remained significant after adjusting for age, cardiovascular risk and global cognition. Conclusion: Increased DTC was associated with higher frontal WMH burden in Lewy body disorders after adjusting for age, cardiovascular risk, and global cognition. Higher DTC was associated with age.

Indexed as

cognitiondual taskgaitLewy body diseaseParkinson’s diseasewhite matter hyperintensities

Identifiers

PMID37091522
PMCPMC10113527
OpenAlexW4362623714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.