Evidence map›Paper›PMID 37091504›Full record

ReviewContemporary clinical trials communications2023

Gender-gap in randomized clinical trials reporting mortality in the perioperative setting and critical care: 20 years behind the scenes.

Carolina S Romero, Nicolò Maimeri, Alessandra Bonaccorso, Martina Baiardo-Redaelli, Gaetano Lombardi, Otito Frances Iwuchukwu, Alessandro Ortalda, Benedikt Schmid, Magdalena Fleming, Giovanni Landoni

Abstract readReview
In one paragraph

Review in Contemporary clinical trials communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carolina S RomeroDepartment of Anesthesia, Critical Care and Pain Unit, University General Hospital, Spain.
Nicolò MaimeriAnesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alessandra BonaccorsoAnesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Martina Baiardo-RedaelliAnesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gaetano LombardiAnesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Otito Frances IwuchukwuAmerican College of Clinical Pharmacology, Fairleigh Dickinson University School of Pharmacy & Health Sciences, New Jersey, United States.
Alessandro OrtaldaAnesthesia and Intensive Care Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Benedikt SchmidDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wurzburg, Wurzburg, Germany.
Magdalena FlemingDepartment of Anaesthesiology and Intensive Care, Czerniakowski Hospital, Warsaw, Poland.
Giovanni LandoniVita-Salute San Raffaele University, Center for Intensive Care and Anesthesiology (CARE) San Raffaele Hospital Head of SIAARTI Clinical Research Committee, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Women researchers might experience obstacles in academic environments and might be underrepresented in the authorship of articles published in peer-reviewed journals. Material and Methods: This is a cross-sectional analysis of female-led RCTs describing all interventions reducing mortality in critically ill and perioperative patients from 1981 to December 31, 2020. We searched PubMed/MEDLINE and EMBASE with the keywords RCTs and mortality. The gender of the first author was extracted and descriptive analysis was performed including the year of publication, impact factor, country of the first author, and methodological aspects. Results: We analyzed 340 RCTs, of which 42 (12%) were led by female researchers. The presence of women increased from 8% (14/172) until 2010 up to 17% (28/168) in 2010 and beyond. The United States, the United Kingdom, and Brazil were the main countries of origin of female researchers. Women authors conducted mainly single-center and single-nation studies as compared to male authors. The median impact factor of the target journal was 6 (3-27) in women vs. 7 (3-28) in men, with a p-value of 0.67; Conclusion: In the last 40 years, only one out of eight RCTs had a woman as the first author but the presence of women increased up to 17% by 2010 and beyond. The impact factor of publication target journals was high and not different between genders.

Indexed as

Critically ill patientDiversityEquityGender gapInclusionRCT

Identifiers

PMID37091504
PMCPMC10119706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.