Evidence map›Paper›PMID 37091419›Full record

ArticleACS omega2023

Novel Glycolipid Chips with a Double Layer of Au Nanoparticles for Biological Toxin Detection.

Hirotaka Uzawa, Takehiro Nagatsuka, Yasuo Seto, Yoshihiro Nishida, Masato Saito, Eiichi Tamiya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hirotaka UzawaNanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba Center, Tsukuba Central, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.ORCID https://orcid.org/0000-0002-3834-8243
Takehiro NagatsukaNanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba Center, Tsukuba Central, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Yasuo SetoNational Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.ORCID https://orcid.org/0000-0002-0983-4162
Yoshihiro NishidaDivision of Applied Biological Chemistry, Graduate School of Environmental Horticulture, Chiba University, Matsudo, Chiba 271-8510, Japan.
Masato SaitoDepartment of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0003-4817-474X
Eiichi TamiyaDepartment of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0002-7646-4827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolipid chips having a double layer of Au nanoparticles are proposed for detection of biological toxins. The sugar-modified chips constitute an under and an upper layer of Au nanoparticles of 20-80 nm diameter on glass plates, and Au nanoparticles of each layer are linked with 1,8-octanedithiol by a self-assembled monolayer (SAM) technique. A tris-sialo glycosphingolipid, ganglioside GT1b, having lipoic amide at the sphingosine part was immobilized on the Au outside surface of the upper layer, and botulinum toxin (type A heavy chain) was detected by localized surface plasmon resonance (LSPR). The GT1b-Cer-coated chip having a double layer of Au nanoparticles enhanced the toxin detection by LSPR more than those with single monolayers. The LSPR response changed according to the sizes of Au nanoparticles in each under and upper layer. The combination of 60 and 40 nm Au nanoparticles in the under and upper layer, respectively, gave the best result, which enabled the toxin detection at concentrations below 5 ng/mL with the portable LSPR device.

Identifiers

PMID37091419
PMCPMC10116526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.