Evidence map›Paper›PMID 37091377›Full record

ArticleACS omega2023

Total Chemical Synthesis of Palmitoyl-Conjugated Insulin.

Mengjie Liu, Qingyang Li, Carlie Delaine, Hongkang Wu, Yanni Arsenakis, Barbara F White, Briony E Forbes, Chaitra Chandrashekar, Mohammed Akhter Hossain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mengjie LiuMonash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Qingyang LiThe Florey Institute of Neuroscience and Mental Health, Parkville 3052, Australia.
Carlie DelaineDiscipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University, Adelaide, South Australia 5042, Australia.
Hongkang WuThe Florey Institute of Neuroscience and Mental Health, Parkville 3052, Australia.
Yanni ArsenakisDepartment of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria 3084, Australia.
Barbara F WhiteDepartment of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria 3084, Australia.
Briony E ForbesDiscipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University, Adelaide, South Australia 5042, Australia.ORCID https://orcid.org/0000-0003-4360-9927
Chaitra ChandrashekarThe Florey Institute of Neuroscience and Mental Health, Parkville 3052, Australia.ORCID https://orcid.org/0000-0002-0288-5952
Mohammed Akhter HossainThe Florey Institute of Neuroscience and Mental Health, Parkville 3052, Australia.ORCID https://orcid.org/0000-0002-9961-0006
Florey Institute of Neuroscience and Mental Health · AUThe University of Melbourne · AUFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Commercially available insulins are manufactured by recombinant methods for the treatment of diabetes. Long-acting insulin drugs (e.g., detemir and degludec) are obtained by fatty acid conjugation at LysB29 ε-amine of insulin via acid-amide coupling. There are three amine groups in insulin, and they all react with fatty acids in alkaline conditions. Due to the lack of selectivity, such conjugation reactions produce non-desired byproducts. We designed and chemically synthesized a novel thiol-insulin scaffold (CysB

Identifiers

PMID37091377
PMCPMC10116525
OpenAlexW4362662556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.