ReviewFrontiers in bioengineering and biotechnology2023
Corneal optical density: Structural basis, measurements, influencing factors, and roles in refractive surgery.
Review in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Preoperative predictive factors for opaque bubble layer formation and area during small-incision lenticule extraction: predictive models based on machine learning.Eye and vision (London, England) · 2026Article
- Seasonal Effects on Corneal Densitometry and Haze After Mitomycin C-Assisted Photorefractive Keratectomy.Journal of clinical medicine · 2026Article
- Automated dual-camera DMD system for stereo optical sectioning imaging.Biomedical optics express · 2026Article
- Corneal optical densitometry in transparent corneas and its correlations with corneal higher-order aberrations.BMC ophthalmology · 2026Article
- Analysis of corneal wavefront aberrations and corneal densitometry in eyes with epithelial basement membrane dystrophy.International ophthalmology · 2026Article
- Linking layered corneal compactness to macroscopic biomechanics:Frontiers in bioengineering and biotechnology · 2026Article
- One-year effects of orthokeratology lens wear on objective visual quality and corneal densitometry in adolescents with myopia.PloS one · 2026Article
- Impact of Superficial Keratectomy on Corneal Topography, Aberration, and Densitometry in Salzmann Nodular Degeneration.Journal of clinical medicine · 2025Article
- Managing Pseudophakic Corneal Edema: Structural Changes and Preliminary Observations on Coenzyme Q10 Use.Korean journal of ophthalmology : KJO · 2025Article
- Impacts and Correlations on Corneal Biomechanics, Corneal Optical Density and Intraocular Pressure after Cataract Surgery.Diagnostics (Basel, Switzerland) · 2024Article
- Corneal Stroma Analysis and Related Ocular Manifestations in Recovered COVID-19 Patients.Investigative ophthalmology & visual science · 2024Article
- The Impact of Standard Cross-Linking on the Corneal Optical Density-Age Relationship in Keratoconus After Mechanical Stripping of the Epithelium.Journal of ophthalmology · 2024Article
- A 6-Month Follow-Up Comparative Study of Single-Step Transepithelial Photorefractive Keratectomy (Trans-PRK) Using the StreamLight Software with and without Epithelial Thickness Customization.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cornea is the main refractive medium of the human eye, and its clarity is critical to visual acuity. Corneal optical density (COD) is an important index to describe corneal transparency. Intact corneal epithelial and endothelial cells, regular arrangement of collagen fibers in the stroma, and normal substance metabolism are all integral for the cornea to maintain its transparency. In the last two decades, the Pentacam Scheimpflug imaging system has emerged as a breakthrough for the measurement of COD (also called corneal densitometry). It has been found that a wide variety of factors such as age, refractive status, and corneal diseases can affect COD. Different corneal refractive surgery methods also change COD in different corneal regions and layers and affect visual acuity following the surgery. Thus, COD has gradually become a significant indicator to evaluate corneal health, one on which the attention of clinicians has been increasingly focused.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.