Evidence map›Paper›PMID 37091190›Full record

ArticleVaccine insights2022

The quest for vaccine-induced immune correlates of protection against tuberculosis.

Elisa Nemes, Andrew Fiore-Gartland, Cesar Boggiano, Margherita Coccia, Patricia D'Souza, Peter Gilbert, Ann Ginsberg, Ollivier Hyrien, Dominick Laddy, Karen Makar and 10 more

Open access · greenAbstract read
In one paragraph

Article in Vaccine insights, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. BCG Revaccination for the Prevention ofThe New England journal of medicine · 2025
    Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Vaccines for Global Health: Progress and Challenges.The Journal of infectious diseases · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. TB-vaccines: Current status & challenges.The Indian journal of medical research · 2024
    Review
  19. OMIP-101: 27-color flow cytometry panel for immunophenotyping of major leukocyte populations in fixed whole blood.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Elisa NemesSouth African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Andrew Fiore-GartlandVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cesar BoggianoNational Institute of Allergy and Infectious Diseases, National Institutes of Health.
Margherita CocciaGSK.
Patricia D'SouzaNational Institute of Allergy and Infectious Diseases, National Institutes of Health.
Peter GilbertVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ann GinsbergBill & Melinda Gates Foundation, Seattle, WA, USA.
Ollivier HyrienVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Dominick LaddyIAVI.
Karen MakarBill & Melinda Gates Foundation, Seattle, WA, USA.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lakshmi RamachandraNational Institute of Allergy and Infectious Diseases, National Institutes of Health.
Alexander C SchmidtBill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Solmaz ShororbaniVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Justine SunshineBill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Georgia TomarasDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Wen-Han YuBill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Nicole FrahmBill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.
BCG Correlates PIs Study Team, M72 Correlates PIs Study Team
Bill & Melinda Gates Foundation · USFred Hutch Cancer Center · USNational Institute of Allergy and Infectious Diseases · USUniversity of Cape Town · ZADuke University · USNational Institutes of Health · US

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
Statistical Methods in HIV Vaccine Efficacy TrialsR37AI054165 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert · 2010 to 2026
$6.7M
NIAID NIH HHS R37 AI054165NIAID NIH HHS UM1 AI068635
6 · The paper itself

Abstract

Immunization strategies against tuberculosis (TB) that confer better protection than neonatal vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to control the epidemic, but clinical development is hampered by a lack of established immune correlates of protection (CoPs). Two phase 2b clinical trials offer the first opportunity to discover human CoPs against TB. Adolescent BCG re-vaccination showed partial protection against

Indexed as

BCGcorrelates of protectionM72/AS01Esystems vaccinologytuberculosis

Identifiers

PMID37091190
PMCPMC10117634
OpenAlexW4299683584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.