Evidence map›Paper›PMID 37091050›Full record

ArticleAdvanced materials interfaces2023

Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On-Chip CRISPR-Cas13a Sensing.

Jacob Waitkus, Yu Chang, Li Liu, Srinivasu Valagerahally Puttaswamy, Taerin Chung, Adrian M Molina Vargas, Stephen J Dollery, Mitchell R O'Connell, Haogang Cai, Gregory J Tobin and 2 more

Abstract read
In one paragraph

Article in Advanced materials interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  14. Article
  15. Localized Surface Plasmon Resonance Sensing and its Interplay with Fluidics.Langmuir : the ACS journal of surfaces and colloids · 2024
    Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jacob WaitkusUniversity of California, Riverside, Riverside, CA, USA.
Yu ChangUniversity of California, Riverside, Riverside, CA, USA.
Li LiuUniversity of California, Riverside, Riverside, CA, USA.
Srinivasu Valagerahally PuttaswamyNIBEC School of Engineering, Ulster University, Belfast, UK.
Taerin ChungTech4Health Institute and Department of Radiology, New York University Langone Health New York, USA.
Adrian M Molina VargasUniversity of Rochester Medical Center, University of Rochester Rochester, USA.
Stephen J DolleryBiological Mimetics Inc, Frederick, MD, USA.
Mitchell R O'ConnellUniversity of Rochester Medical Center, University of Rochester Rochester, USA.
Haogang CaiTech4Health Institute and Department of Radiology, New York University Langone Health New York, USA.
Gregory J TobinBiological Mimetics Inc, Frederick, MD, USA.
Nikhil BhallaNIBEC School of Engineering, Ulster University, Belfast, UK.
Ke DuUniversity of California, Riverside, Riverside, CA, USA.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Programmable RNA-targeting CRISPR-Cas tools to study RNA biologyR35GM133462 · NIGMS · UNIVERSITY OF ROCHESTER · PI Mitchell O'Connell · 2019 to 2026
$3.6M
Understand and Detect Sepsis: Pathogen Isolation, Biochemistry Assay, and Optofluidic SensingR35GM142763 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DU, KE · 2021 to 2025
$2.0M
NCATS NIH HHS UL1 TR002001NIGMS NIH HHS R35 GM133462NIGMS NIH HHS R35 GM142763
6 · The paper itself

Abstract

A novel localized surface plasmon resonance (LSPR) system based on the coupling of gold nanomushrooms (AuNMs) and gold nanoparticles (AuNPs) is developed to enable a significant plasmonic resonant shift. The AuNP size, surface chemistry, and concentration are characterized to maximize the LSPR effect. A 31 nm redshift is achieved when the AuNMs are saturated by the AuNPs. This giant redshift also increases the full width of the spectrum and is explained by the 3D finite-difference time-domain (FDTD) calculation. In addition, this LSPR substrate is packaged in a microfluidic cell and integrated with a CRISPR-Cas13a RNA detection assay for the detection of the SARS-CoV-2 RNA targets. Once activated by the target, the AuNPs are cleaved from linker probes and randomly deposited on the AuNM substrate, demonstrating a large redshift. The novel LSPR chip using AuNP as an indicator is simple, specific, isothermal, and label-free; and thus, provides a new opportunity to achieve the next generation multiplexing and sensitive molecular diagnostic system.

Indexed as

CRISPR-Cas13afinite difference time domaingold nanomushroomgold nanoparticlelocalized surface plasmon resonance (LSPR)microfluidicsSARS-CoV-2

Identifiers

PMID37091050
PMCPMC10121183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.