Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report.

Elena Barbuti, Riccardo Nistri, Antonio Ianniello, Carlo Pozzilli, Serena Ruggieri

Open access · goldAbstract readCase Reports

In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Pediatric Radiologically Isolated Syndrome (RIS): A Case with Active Disease 18 Years Later.Neurology and therapy · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elena BarbutiMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Riccardo NistriMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Antonio IannielloMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Carlo PozzilliMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Serena RuggieriDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Sapienza University of Rome · ITFondazione Santa Lucia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Radiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment in selected patients might improve long-term outcomes. Case presentation: We report a single RIS patient who followed up for 18 years in our MS center. At first, she was only monitored with follow-up MRIs. Then, as the lesion load increased, she was treated with a first-line disease-modifying treatment (DMT) reaching MRI stability. Conclusion: This report highlights how treatment can be an appropriate choice in pediatric forms of RIS.

Indexed as

childrenmultiple sclerosispediatric radiologically isolated syndromeRIStreatment

Identifiers

PMID37090972

DOI10.3389/fneur.2023.1145260

PMCPMC10117757

OpenAlexW4362671293

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.