ArticleClinical and translational radiation oncology2023
Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy.
Article in Clinical and translational radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- One-for-All Adaptive Radiotherapy Planning Agent: A Foundation Framework for Daily CBCT-guided Radiotherapy.ArXiv · 2026Article
- Impact of reduced robustness settings on the necessity for proton therapy treatment plan adaptation in head-and-neck cancer patients.Physics and imaging in radiation oncology · 2026Article
- Reduction of organ of interest dose in proton therapy for oesophageal cancer through optimized setup robustness settings and online adaptation.Physics and imaging in radiation oncology · 2026Article
- Terminology Proposal for Adaptive Particle Therapy Classification and Strategies.International journal of particle therapy · 2026Article
- Time-saving potential of daily online adaptive proton therapy for head and neck cancers by reducing number of beams.Physics and imaging in radiation oncology · 2025Article
- Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Enhancing accuracy in proton therapy: The impact of geometric uncertainty models in head and neck cancer treatment.Medical physics · 2025Article
- Cone Beam Computed Tomography in Oral Cancer: A Scoping Review.Diagnostics (Basel, Switzerland) · 2025Review
- A planning approach for online adaptive proton therapy to cope with cone beam computed tomography inaccuracies.Physics and imaging in radiation oncology · 2025Article
- Current status and upcoming developments for online adaptive proton therapy enabling a closed feedback loop for near real-time adaptation.Frontiers in oncology · 2025Review
- Clinical advantages of incorporating predicted weekly anatomy in IMPT optimization with reduced setup error.Medical physics · 2024Article
- Article
- A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer.Journal of applied clinical medical physics · 2024Article
- Surveying the clinical practice of treatment adaptation and motion management in particle therapy.Physics and imaging in radiation oncology · 2023Article
- Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy.Physics in medicine and biology · 2023Article
- Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes. Methods: IMPT treatment plans are created retrospectively for a cohort of eight H&N cancer patients that previously required replanning during the course of treatment due to large anatomical changes. Daily cone-beam CTs (CBCT) are acquired and corrected for scatter, resulting in 253 analyzed fractions. To simulate the FOR workflow, nominal plans are created on the planning-CT and delivered until a repeated-CT is acquired; at this point, a new plan is created on the repeated-CT. To simulate the OA workflow, nominal plans are created on the planning-CT and adapted at each fraction using a simple beamlet weight-tuning technique. Dose distributions are calculated on the CBCTs with Monte Carlo for both delivery methods. The total treatment dose is accumulated on the planning-CT. Results: Daily OA improved target coverage compared to FOR despite using smaller target margins. In the high-risk CTV, the median D Conclusion: Daily OA can maintain prescription doses and constraints over the course of fractionated treatment, even in cases of large anatomical changes, reducing the necessity for manual replanning in H&N IMPT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.